TH287
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406660

CAS#: 1609960-30-6

Description: TH287 is a potent inhibitor of human 7,8-Dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1) with an IC50 value of 5 nM and good metabolic stability. Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. TH287 a first-in-class nudix hydrolase family inhibitor that potently and selectively engages and inhibits the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitor binds in the active site of MTH1.

Chemical Structure

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TH287
CAS# 1609960-30-6
Instruction

Theoretical Analysis

MedKoo Cat#: 406660
Name: TH287
CAS#: 1609960-30-6
Chemical Formula: C11H10Cl2N4
Exact Mass: 268.03
Molecular Weight: 269.130
Elemental Analysis: C, 49.09; H, 3.75; Cl, 26.34; N, 20.82

Price and Availability

Size Price Availability Quantity
100mg USD 650
200mg USD 950
500mg USD 1650
1g USD 2850
2g USD 3950
5g USD 6450
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Synonym: TH287; TH 287; TH-287.

IUPAC/Chemical Name: 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine

InChi Key: URWCXPXBBITYLR-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H10Cl2N4/c1-15-9-5-8(16-11(14)17-9)6-3-2-4-7(12)10(6)13/h2-5H,1H3,(H3,14,15,16,17)

SMILES Code: NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:
Product Data
Instruction:
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Preparing Stock Solutions

The following data is based on the product molecular weight 269.130000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Saleh A, Gökturk C, Warpman-Berglund U, Helleday T, Granelli I. Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma. J Pharm Biomed Anal. 2015 Feb;104:1-11. doi: 10.1016/j.jpba.2014.11.009. Epub 2014 Nov 15. PubMed PMID: 25459754.