WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556028
Description: AFN39186, also known as RAD51-IN-1, is a derivative of B02 and a potent inhibitor of RAD51. AFN39186 was first reported in Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100.. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 556028
Chemical Formula: C22H16ClN3O
Exact Mass: 373.0982
Molecular Weight: 373.84
Elemental Analysis: C, 70.68; H, 4.31; Cl, 9.48; N, 11.24; O, 4.28
Synonym: RAD51-IN-1; AFN39186; AFN-39186; AFN 39186;
IUPAC/Chemical Name: (E)-3-(4-chlorobenzyl)-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one
InChi Key: AQNDWTVLZSMOQU-FMIVXFBMSA-N
InChi Code: InChI=1S/C22H16ClN3O/c23-18-10-7-17(8-11-18)15-26-21(12-9-16-4-3-13-24-14-16)25-20-6-2-1-5-19(20)22(26)27/h1-14H,15H2/b12-9+
SMILES Code: O=C1N(CC2=CC=C(Cl)C=C2)C(/C=C/C3=CC=CN=C3)=NC4=C1C=CC=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 373.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Ward A, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100.