AFN39186
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MedKoo CAT#: 556028

CAS#: 2101739-18-6

Description: AFN39186, also known as RAD51-IN-1, is a derivative of B02 and a potent inhibitor of RAD51. AFN39186 was first reported in Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100.. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).


Chemical Structure

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AFN39186
CAS# 2101739-18-6

Theoretical Analysis

MedKoo Cat#: 556028
Name: AFN39186
CAS#: 2101739-18-6
Chemical Formula: C22H16ClN3O
Exact Mass: 373.0982
Molecular Weight: 373.84
Elemental Analysis: C, 70.68; H, 4.31; Cl, 9.48; N, 11.24; O, 4.28

Price and Availability

Size Price Availability Quantity
100.0mg USD 1250.0 2 Weeks
200.0mg USD 1950.0 2 Weeks
500.0mg USD 2950.0 2 Weeks
1.0g USD 3950.0 2 Weeks
2.0g USD 5950.0 2 Weeks
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Synonym: RAD51-IN-1; AFN39186; AFN-39186; AFN 39186;

IUPAC/Chemical Name: (E)-3-(4-chlorobenzyl)-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one

InChi Key: AQNDWTVLZSMOQU-FMIVXFBMSA-N

InChi Code: InChI=1S/C22H16ClN3O/c23-18-10-7-17(8-11-18)15-26-21(12-9-16-4-3-13-24-14-16)25-20-6-2-1-5-19(20)22(26)27/h1-14H,15H2/b12-9+

SMILES Code: O=C1N(CC2=CC=C(Cl)C=C2)C(/C=C/C3=CC=CN=C3)=NC4=C1C=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 373.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Ward A, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100.

AFN39186

100.0mg / USD 1250.0