WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465543
CAS#: unknown
Description: PY-60 is a novel activator of YAP, promoting expansion of epidermal keratinocytes ex vivo and in vivo, targeting ANXA2 to activate YAP, activating a robust, YAP- dependent transcriptional program in multiple cell types. Chemical proteomics revealed the relevant target of PY-60 to be annexin A2 (ANXA2), a protein that directly associates with YAP at the cell membrane in response to increased cell density. PY-60 treatment liberates ANXA2 from the membrane, ultimately promoting a phosphatase-bound, nonphosphorylated and transcriptionally active form of YAP.
MedKoo Cat#: 465543
Name: PY-60
CAS#: unknown
Chemical Formula: C16H15N3O2S
Exact Mass: 313.0885
Molecular Weight: 313.375
Elemental Analysis: C, 61.32; H, 4.82; N, 13.41; O, 10.21; S, 10.23
Synonym: PY-60; PY 60; PY60;
IUPAC/Chemical Name: 5-phenyl-N-(3-(thiazol-2-yl)propyl)isoxazole-3-carboxamide
InChi Key: UFASECSYKSMYET-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H15N3O2S/c20-16(18-8-4-7-15-17-9-10-22-15)13-11-14(21-19-13)12-5-2-1-3-6-12/h1-3,5-6,9-11H,4,7-8H2,(H,18,20)
SMILES Code: O=C(C1=NOC(C2=CC=CC=C2)=C1)NCCCC3=NC=CS3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 313.375 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Shalhout SZ, Yang PY, Grzelak EM, Nutsch K, Shao S, Zambaldo C, Iaconelli J, Ibrahim L, Stanton C, Chadwick SR, Chen E, DeRan M, Li S, Hull M, Wu X, Chatterjee AK, Shen W, Camargo FD, Schultz PG, Bollong MJ. YAP-dependent proliferation by a small molecule targeting annexin A2. Nat Chem Biol. 2021 Jul;17(7):767-775. doi: 10.1038/s41589-021-00755-0. Epub 2021 Mar 15. PMID: 33723431.
