WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556025
Description: CUN79177, also known as BRM/BRG1 ATP Inhibitor-1, is an orally Active Inhibitors (IC50=5 nM) of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. CUN79177 was first reported ion Journal of Medicinal Chemistry (2018), 61(22), 10155-10172. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 556025
Chemical Formula: C11H9F3N4O2S
Exact Mass: 318.0398
Molecular Weight: 318.2742
Elemental Analysis: C, 41.51; H, 2.85; F, 17.91; N, 17.60; O, 10.05; S, 10.07
Synonym: BRM/BRG1 ATP Inhibitor-1; CUN79177; CUN79177; CUN-79177;
IUPAC/Chemical Name: 1-[3-(Difluoromethyl)isothiazol-5-yl]-3-[2-fluoro-5-(hydroxymethyl)pyridin-4-yl]urea
InChi Key: CKYCAIAVJIFWPE-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H9F3N4O2S/c12-8-1-6(5(4-19)3-15-8)16-11(20)17-9-2-7(10(13)14)18-21-9/h1-3,10,19H,4H2,(H2,15,16,17,20)
SMILES Code: O=C(NC1=CC(F)=NC=C1CO)NC2=CC(C(F)F)=NS2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 318.2742 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|