BAY-8400
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MedKoo CAT#: 465423

CAS#: unknown

Description: BAY-8400 is a novel selective inhibitor of DNA-PK. In in vitro studies, BAY-8400 showed synergistic activity of DNA-PK inhibition with DNA damage-inducing targeted alpha therapy. Combination of PSMA-targeted thorium-227 conjugate BAY 2315497 treatment of human prostate tumor-bearing mice with BAY-8400 oral treatment increased antitumor efficacy, as compared to PSMA-targeted thorium-227 conjugate monotherapy.

Chemical Structure

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BAY-8400
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 465423
Name: BAY-8400
CAS#: unknown
Chemical Formula: C21H17F2N5O
Exact Mass: 393.14
Molecular Weight: 393.398
Elemental Analysis: C, 64.12; H, 4.36; F, 9.66; N, 17.80; O, 4.07

Price and Availability

Size Price Availability Quantity
25mg USD 1250 2 Weeks
50mg USD 1950 2 Weeks
100mg USD 3650 2 Weeks
200mg USD 4950 2 Weeks
500mg USD 6950 2 Weeks
1g USD 11950 2 Weeks
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Synonym: BAY-8400; BAY8400; BAY 8400;

IUPAC/Chemical Name: 8-(5-(difluoromethyl)pyridin-3-yl)-1-(2,3,6,7-tetrahydrooxepin-4-yl)-[1,2,4]triazolo[4,3-a]quinoxaline

InChi Key: ATKHYZXUMVNCIO-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H17F2N5O/c22-20(23)16-8-15(10-24-11-16)14-3-4-17-18(9-14)28-19(12-25-17)26-27-21(28)13-2-1-6-29-7-5-13/h2-4,8-12,20H,1,5-7H2

SMILES Code: FC(C1=CN=CC(C2=CC3=C(C=C2)N=CC4=NN=C(C5=CCCOCC5)N43)=C1)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 393.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Berger M, Wortmann L, Buchgraber P, Lücking U, Zitzmann-Kolbe S, Wengner AM, Bader B, Bömer U, Briem H, Eis K, Rehwinkel H, Bartels F, Moosmayer D, Eberspächer U, Lienau P, Hammer S, Schatz CA, Wang Q, Wang Q, Mumberg D, Nising CF, Siemeister G. BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies. J Med Chem. 2021 Aug 24. doi: 10.1021/acs.jmedchem.1c00762. Epub ahead of print. PMID: 34428039.