K-25a

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465422

CAS#: unknown

Description: K-25a is a non-nucleoside reverse Transcriptase inhibitor (NNRTI).

Chemical Structure

img
K-25a
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 465422
Name: K-25a
CAS#: unknown
Chemical Formula: C29H30N6O3S2
Exact Mass: 574.18
Molecular Weight: 574.718
Elemental Analysis: C, 60.61; H, 5.26; N, 14.62; O, 8.35; S, 11.16

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: K-25a; K25a; K 25a;

IUPAC/Chemical Name: (E)-4-((4-((4-(4-(2-cyanovinyl)-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzenesulfonamide

InChi Key: GVCHBMCBPBRORW-ONEGZZNKSA-N

InChi Code: InChI=1S/C29H30N6O3S2/c1-19-16-22(4-3-12-30)17-20(2)26(19)38-28-27-25(11-15-39-27)33-29(34-28)32-23-9-13-35(14-10-23)18-21-5-7-24(8-6-21)40(31,36)37/h3-8,11,15-17,23H,9-10,13-14,18H2,1-2H3,(H2,31,36,37)(H,32,33,34)/b4-3+

SMILES Code: CC1=CC(/C=C/C#N)=CC(C)=C1OC2=C(SC=C3)C3=NC(NC4CCN(CC5=CC=C(S(=O)(N)=O)C=C5)CC4)=N2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 574.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Renner N, Mallery DL, Faysal KMR, Peng W, Jacques DA, Böcking T, James LC. A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly. PLoS Pathog. 2021 Feb 1;17(2):e1009164. doi: 10.1371/journal.ppat.1009164. PMID: 33524070; PMCID: PMC7850482.

2: Stansell E, Apkarian R, Haubova S, Diehl WE, Tytler EM, Hunter E. Basic residues in the Mason-Pfizer monkey virus gag matrix domain regulate intracellular trafficking and capsid-membrane interactions. J Virol. 2007 Sep;81(17):8977-88. doi: 10.1128/JVI.00657-07. Epub 2007 Jun 27. PMID: 17596311; PMCID: PMC1951391.

3: Martins A, Shuman S. Mutational analysis of baculovirus phosphatase identifies structural residues important for triphosphatase activity in vitro and in vivo. Biochemistry. 2002 Nov 12;41(45):13403-9. doi: 10.1021/bi0265426. PMID: 12416985.