WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406626
CAS#: 856693-04-4
Description: CEP-14513 is a potent ALK inhibitor. CEP-14513 displayed potent ALK inhibitory activity in both in vitro enzymatic assay (IC50 = 5 nM) and cell-based assays of ALK tyrosine phosphorylation (IC50 = 30 nM).
MedKoo Cat#: 406626
Name: CEP-14513
CAS#: 856693-04-4
Chemical Formula: C34H36N6O3
Exact Mass: 576.28489
Molecular Weight: 576.69
Elemental Analysis: C, 70.81; H, 6.29; N, 14.57; O, 8.32
Synonym: CEP14513; CEP 14513; CEP-14513.
IUPAC/Chemical Name: 13-isobutyl-4-methyl-6-oxo-2,4,6,7,8,13-hexahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-10-yl 4-(dimethylamino)benzylcarbamate
InChi Key: ZFKJDNACAGAYFJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C34H36N6O3/c1-19(2)17-40-28-13-10-22(43-34(42)36-15-20-6-8-21(9-7-20)38(3)4)14-24(28)30-25-16-35-33(41)31(25)29-23(32(30)40)11-12-27-26(29)18-39(5)37-27/h6-10,13-14,18-19H,11-12,15-17H2,1-5H3,(H,35,41)(H,36,42)
SMILES Code: O=C(OC1=CC=C(N(CC(C)C)C2=C3C4=C(C(NC4)=O)C5=C2CCC6=NN(C)C=C65)C3=C1)NCC7=CC=C(N(C)C)C=C7
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 576.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Haack, H.; Crosby, K. E.; Rimkunas, V. M.; Silver, M. R. Anaplastic lymphoma kinase in kidney cancer. WO2012019132A2.
