9-Me-BC | CAS#2521-07-5 | Nootropic reference standard

9-Me-BC
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465405

CAS#: 2521-07-5

Description: 9-Me-BC is an analytical reference standard categorized as a nootropic. 9-Methyl-β-carboline improves spatial learning in rats. This product is intended for research and forensic applications. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).

Chemical Structure

9-Me-BC

CAS# 2521-07-5

Instruction

Theoretical Analysis

MedKoo Cat#: 465405
Name: 9-Me-BC
CAS#: 2521-07-5
Chemical Formula: C12H10N2
Exact Mass: 182.08
Molecular Weight: 182.226
Elemental Analysis: C, 79.10; H, 5.53; N, 15.37

Price and Availability

Size	Price	Availability
1mg	USD 220	2 Weeks
5mg	USD 380	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: 9-Me-BC; 9-MeBC; 9-Me BC; 9Me-BC; 9 Me-BC; 9MeBC; 9 Me BC; 9-Methyl-BC; 9-Methyl-norharman; 9-Methyl-β-carboline;

IUPAC/Chemical Name: 9-methyl-9H-pyrido[3,4-b]indole

InChi Key: MABOIYXDALNSES-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H10N2/c1-14-11-5-3-2-4-9(11)10-6-7-13-8-12(10)14/h2-8H,1H3

SMILES Code: CN1C2=C(C3=C1C=NC=C3)C=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMF	20.0	109.75
	DMSO	20.0	109.75
	DMSO:PBS (pH 7.2) (1:3)	0.3	1.81

Preparing Stock Solutions

The following data is based on the product molecular weight 182.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Keller S, Polanski WH, Enzensperger C, Reichmann H, Hermann A, Gille G. 9-Methyl-β-carboline inhibits monoamine oxidase activity and stimulates the expression of neurotrophic factors by astrocytes. J Neural Transm (Vienna). 2020 Jul;127(7):999-1012. doi: 10.1007/s00702-020-02189-9. Epub 2020 Apr 13. PMID: 32285253.

2: Rasse-Suriani FAO, García-Einschlag FS, Rafti M, Schmidt De León T, David Gara PM, Erra-Balsells R, Cabrerizo FM. Photophysical and Photochemical Properties of Naturally Occurring normelinonine F and Melinonine F Alkaloids and Structurally Related N(2)- and/or N(9)-methyl-β-carboline Derivatives. Photochem Photobiol. 2018 Jan;94(1):36-51. doi: 10.1111/php.12811. Epub 2017 Sep 20. PMID: 28741707.

3: Vignoni M, Rasse-Suriani FA, Butzbach K, Erra-Balsells R, Epe B, Cabrerizo FM. Mechanisms of DNA damage by photoexcited 9-methyl-β-carbolines. Org Biomol Chem. 2013 Aug 28;11(32):5300-9. doi: 10.1039/c3ob40344k. PMID: 23842892.

4: Santos CM. New agents promote neuroprotection in Parkinson's disease models. CNS Neurol Disord Drug Targets. 2012 Jun 1;11(4):410-8. doi: 10.2174/187152712800792820. PMID: 22483311.

5: Gruss M, Appenroth D, Flubacher A, Enzensperger C, Bock J, Fleck C, Gille G, Braun K. 9-Methyl-β-carboline-induced cognitive enhancement is associated with elevated hippocampal dopamine levels and dendritic and synaptic proliferation. J Neurochem. 2012 Jun;121(6):924-31. doi: 10.1111/j.1471-4159.2012.07713.x. PMID: 22380576.

6: Gulyaeva N, Aniol V. Good guys from a shady family. J Neurochem. 2012 Jun;121(6):841-2. doi: 10.1111/j.1471-4159.2012.07708.x. PMID: 22372749.

7: Polanski W, Reichmann H, Gille G. Stimulation, protection and regeneration of dopaminergic neurons by 9-methyl-β-carboline: a new anti-Parkinson drug? Expert Rev Neurother. 2011 Jun;11(6):845-60. doi: 10.1586/ern.11.1. PMID: 21651332.

8: Herraiz T, Guillén H. Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors. Food Chem Toxicol. 2011 Aug;49(8):1773-81. doi: 10.1016/j.fct.2011.04.026. Epub 2011 Apr 29. PMID: 21554916.

9: Polanski W, Enzensperger C, Reichmann H, Gille G. The exceptional properties of 9-methyl-beta-carboline: stimulation, protection and regeneration of dopaminergic neurons coupled with anti-inflammatory effects. J Neurochem. 2010 Jun;113(6):1659-75. doi: 10.1111/j.1471-4159.2010.06725.x. Epub 2010 Mar 31. PMID: 20374418.

10: Wernicke C, Hellmann J, Zieba B, Kuter K, Ossowska K, Frenzel M, Dencher NA, Rommelspacher H. 9-Methyl-beta-carboline has restorative effects in an animal model of Parkinson's disease. Pharmacol Rep. 2010 Jan-Feb;62(1):35-53. doi: 10.1016/s1734-1140(10)70241-3. PMID: 20360614.

11: Coronilla AS, Carmona C, Muñoz MA, Balón M. Singlet excited state pyridinic deprotonation of the N9-methylbetacarboline cations in aqueous sodium hydroxide solutions. J Fluoresc. 2010 Jan;20(1):163-70. doi: 10.1007/s10895-009-0534-3. PMID: 19705259.

12: Sánchez Coronilla A, Carmona C, Muñoz MA, Balón M. Ground and singlet excited state pyridinic protonation of N9-methylbetacarboline in water-N,N-dimethylformamide mixtures. J Fluoresc. 2009 Nov;19(6):1025-35. doi: 10.1007/s10895-009-0502-y. Epub 2009 Jun 18. PMID: 19536642.

13: Hamann J, Wernicke C, Lehmann J, Reichmann H, Rommelspacher H, Gille G. 9-Methyl-beta-carboline up-regulates the appearance of differentiated dopaminergic neurones in primary mesencephalic culture. Neurochem Int. 2008 Mar- Apr;52(4-5):688-700. doi: 10.1016/j.neuint.2007.08.018. Epub 2007 Sep 4. PMID: 17913302.

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