WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465343

CAS#: unknown

Description: K-476 is a novel tankyrase inhibitor, enhancing the efficacy of immune checkpoint inhibitor by attracting CD8+ T cells to tumors.

Chemical Structure

CAS# unknown

Theoretical Analysis

MedKoo Cat#: 465343
Name: K-476
CAS#: unknown
Chemical Formula: C31H29FN6O3
Exact Mass: 552.2285
Molecular Weight: 552.6104
Elemental Analysis: C, 67.38; H, 5.29; F, 3.44; N, 15.21; O, 8.69

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: K-476; K476; K 476;

IUPAC/Chemical Name: 5-(3-((1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl)methyl)-2-oxo-3,4-dihydroquinazolin-1(2H)-yl)-2-fluorobenzonitrile


InChi Code: InChI=1S/C31H29FN6O3/c1-40-28-14-24-26(15-29(28)41-2)34-19-35-30(24)36-11-9-20(10-12-36)17-37-18-21-5-3-4-6-27(21)38(31(37)39)23-7-8-25(32)22(13-23)16-33/h3-8,13-15,19-20H,9-12,17-18H2,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 552.6104 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kinosada H, Okada-Iwasaki R, Kunieda K, Suzuki-Imaizumi M, Takahashi Y, Miyagi H, Suzuki M, Motosawa K, Watanabe M, Mie M, Ishii T, Ishida H, Saito JI, Nakai R. The dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8+ T cells to tumors. Am J Cancer Res. 2021 Jan 1;11(1):264-276. PMID: 33520373; PMCID: PMC7840722.