WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465343
CAS#: unknown
Description: K-476 is a novel tankyrase inhibitor, enhancing the efficacy of immune checkpoint inhibitor by attracting CD8+ T cells to tumors.
MedKoo Cat#: 465343
Name: K-476
CAS#: unknown
Chemical Formula: C31H29FN6O3
Exact Mass: 552.2285
Molecular Weight: 552.6104
Elemental Analysis: C, 67.38; H, 5.29; F, 3.44; N, 15.21; O, 8.69
This product is not in stock, which may be available by custom synthesis.
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Synonym: K-476; K476; K 476;
IUPAC/Chemical Name: 5-(3-((1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl)methyl)-2-oxo-3,4-dihydroquinazolin-1(2H)-yl)-2-fluorobenzonitrile
InChi Key: STWRRCLLHUNQOS-UHFFFAOYSA-N
InChi Code: InChI=1S/C31H29FN6O3/c1-40-28-14-24-26(15-29(28)41-2)34-19-35-30(24)36-11-9-20(10-12-36)17-37-18-21-5-3-4-6-27(21)38(31(37)39)23-7-8-25(32)22(13-23)16-33/h3-8,13-15,19-20H,9-12,17-18H2,1-2H3
SMILES Code: N#CC1=CC(N2C(N(CC3CCN(C4=C5C=C(OC)C(OC)=CC5=NC=N4)CC3)CC6=C2C=CC=C6)=O)=CC=C1F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 552.6104 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Kinosada H, Okada-Iwasaki R, Kunieda K, Suzuki-Imaizumi M, Takahashi Y, Miyagi H, Suzuki M, Motosawa K, Watanabe M, Mie M, Ishii T, Ishida H, Saito JI, Nakai R. The dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8+ T cells to tumors. Am J Cancer Res. 2021 Jan 1;11(1):264-276. PMID: 33520373; PMCID: PMC7840722.
