MedKoo Biosciences

SYP-5
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465290

CAS#: 1384268-04-5

Description: SYP-5 is an inhibitor of hypoxia-inducible factor-1 (HIF-1). It inhibits HIF-1 activity in a reporter assay when used at concentrations ranging from 0.1 to 100 µM. SYP-5 (2, 10, and 50 µM) reduces hypoxia- or VEGF-induced capillary tube formation in human umbilical vein endothelial cells (HUVECs). It inhibits the migration and invasion of Hep3B hepatocellular carcinoma and BCaP-37 breast cancer cells in a concentration-dependent manner.

Chemical Structure

SYP-5

CAS# 1384268-04-5

Instruction

Theoretical Analysis

MedKoo Cat#: 465290
Name: SYP-5
CAS#: 1384268-04-5
Chemical Formula: C18H16O3S
Exact Mass: 312.08
Molecular Weight: 312.383
Elemental Analysis: C, 69.21; H, 5.16; O, 15.36; S, 10.26

Price and Availability

Size	Price	Availability
25mg	USD 250	2 Weeks
50mg	USD 450	2 Weeks
100mg	USD 750	2 Weeks
200mg	USD 1250	2 Weeks
500mg	USD 2650	2 Weeks
1g	USD 3850	2 Weeks
2g	USD 5850	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 1384268-04-5;

Synonym: SYP-5; SYP5; SYP 5;

IUPAC/Chemical Name: (E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(thiophen-2-yl)prop-2-en-1-one

InChi Key: OMVURDVBYIJCOI-FNORWQNLSA-N

InChi Code: InChI=1S/C18H16O3S/c1-18(2)10-9-14-16(21-18)8-6-13(17(14)20)15(19)7-5-12-4-3-11-22-12/h3-11,20H,1-2H3/b7-5+

SMILES Code: OC1=C2C(OC(C=C2)(C)C)=CC=C1C(/C=C/C3=CC=CS3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Product Data

Instruction:

View handling instruction

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMF	30.0	96.04
	DMF:PBS (pH 7.2) (1:2)	0.3	0.96
	DMSO	25.0	80.03
	Ethanol	1.0	3.20

Preparing Stock Solutions

The following data is based on the product molecular weight 312.383000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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1: Liu Y, Zhao Q, Nie H, Zhang F, Fu T, Zhang Z, Qi F, Wang R, Zhou J, Gao J. SYP-5 regulates meiotic thermotolerance in Caenorhabditis elegans. J Mol Cell Biol. 2021 Jun 3:mjab035. doi: 10.1093/jmcb/mjab035. Epub ahead of print. PMID: 34081106. 2: Zheng L, Wang B, Sun Y, Dai B, Fu Y, Zhang Y, Wang Y, Yang Z, Sun Z, Zhuang S, Zhang D. An Oxygen-Concentration-Controllable Multiorgan Microfluidic Platform for Studying Hypoxia-Induced Lung Cancer-Liver Metastasis and Screening Drugs. ACS Sens. 2021 Mar 26;6(3):823-832. doi: 10.1021/acssensors.0c01846. Epub 2021 Mar 3. PMID: 33657793. 3: Zhang Z, Xie S, Wang R, Guo S, Zhao Q, Nie H, Liu Y, Zhang F, Chen M, Liu L, Meng X, Liu M, Zhao L, Colaiácovo MP, Zhou J, Gao J. Multivalent weak interactions between assembly units drive synaptonemal complex formation. J Cell Biol. 2020 May 4;219(5):e201910086. doi: 10.1083/jcb.201910086. PMID: 32211900; PMCID: PMC7199860. 4: Hurlock ME, Čavka I, Kursel LE, Haversat J, Wooten M, Nizami Z, Turniansky R, Hoess P, Ries J, Gall JG, Rog O, Köhler S, Kim Y. Identification of novel synaptonemal complex components in C. elegans. J Cell Biol. 2020 May 4;219(5):e201910043. doi: 10.1083/jcb.201910043. PMID: 32211899; PMCID: PMC7199856. 5: Wang LH, Jiang XR, Yang JY, Bao XF, Chen JL, Liu X, Chen GL, Wu CF. SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. Eur J Pharmacol. 2016 Nov 15;791:560-568. doi: 10.1016/j.ejphar.2016.09.027. Epub 2016 Sep 21. PMID: 27664769.

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