93-O17S
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465286

CAS#: 2227008-67-3

Description: 93-O17S is a chalcogen-containing cationic lipidoid. It has been used in the synthesis of lipid nanoparticles (LPNs) for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice. LPNs containing 93-O17S have been used for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens and stimulation of interferon genes (STING) activation in a B16/F10 murine melanoma model.

Chemical Structure

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93-O17S
CAS# 2227008-67-3
Instruction

Theoretical Analysis

MedKoo Cat#: 465286
Name: 93-O17S
CAS#: 2227008-67-3
Chemical Formula: C44H83N3O4S2
Exact Mass: 781.58
Molecular Weight: 782.285
Elemental Analysis: C, 67.56; H, 10.69; N, 5.37; O, 8.18; S, 8.20

Price and Availability

Size Price Availability Quantity
25mg USD 360 2 Weeks
50mg USD 610 2 Weeks
100mg USD 990 2 Weeks
250mg USD 1640 2 Weeks
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Synonym: 93-O17S; 93O17S; 93 O17S;

IUPAC/Chemical Name: bis(2-(tetradecylthio)ethyl) 3,3'-((3-(1H-imidazol-1-yl)propyl)azanediyl)dipropionate

InChi Key: OLOIOPYNTGMAAP-UHFFFAOYSA-N

InChi Code: InChI=1S/C44H83N3O4S2/c1-3-5-7-9-11-13-15-17-19-21-23-25-38-52-40-36-50-43(48)28-33-46(31-27-32-47-35-30-45-42-47)34-29-44(49)51-37-41-53-39-26-24-22-20-18-16-14-12-10-8-6-4-2/h30,35,42H,3-29,31-34,36-41H2,1-2H3

SMILES Code: O=C(CCN(CCC(OCCSCCCCCCCCCCCCCC)=O)CCCN1C=NC=C1)OCCSCCCCCCCCCCCCCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Chloroform 100.0 127.83

Preparing Stock Solutions

The following data is based on the product molecular weight 782.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chen J, Qiu M, Ye Z, Nyalile T, Li Y, Glass Z, Zhao X, Yang L, Chen J, Xu Q. In situ cancer vaccination using lipidoid nanoparticles. Sci Adv. 2021 May 5;7(19):eabf1244. doi: 10.1126/sciadv.abf1244. PMID: 33952519; PMCID: PMC8099179.