WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406601

CAS#: 199596-05-9

Description: JIB-04, also known as NSC 693627, is a Jumonji histone demethylase inhibitor. JIB-04 selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. JIB-04 can prolong survival in a mouse model of breast cancer.

Chemical Structure

CAS# 199596-05-9

Theoretical Analysis

MedKoo Cat#: 406601
Name: JIB-04
CAS#: 199596-05-9
Chemical Formula: C17H13ClN4
Exact Mass: 308.08287
Molecular Weight: 308.76
Elemental Analysis: C, 66.13; H, 4.24; Cl, 11.48; N, 18.15

Price and Availability

Size Price Availability Quantity
200.0mg USD 1250.0 2 Weeks
500.0mg USD 2250.0 2 Weeks
1.0g USD 3450.0 2 Weeks
2.0g USD 4750.0 2 Weeks
5.0g USD 6250.0 2 Weeks
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Related CAS #: 199596-05-9 (JIB04)   199596-24-2 (JIB04 Z-isomer)    

Synonym: JIB04; JIB-04; JIB 04; NSC 693627; NSC-693627; NSC 693627.

IUPAC/Chemical Name: (E)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine


InChi Code: InChI=1S/C17H13ClN4/c18-14-9-10-16(20-12-14)21-22-17(13-6-2-1-3-7-13)15-8-4-5-11-19-15/h1-12H,(H,20,21)/b22-17+

SMILES Code: ClC1=CN=C(N/N=C(C2=CC=CC=C2)/C3=NC=CC=C3)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 308.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Van Rechem C, Black JC, Boukhali M, Aryee MJ, Graslund S, Haas W, Benes CH, Whetstine JR. Lysine Demethylase KDM4A Associates with Translation Machinery and Regulates Protein Synthesis. Cancer Discov. 2015 Jan 6. pii: CD-14-1326. [Epub ahead of print] PubMed PMID: 25564516.

2: Sekar TV, Foygel K, Gelovani JG, Paulmurugan R. Genetically Encoded Molecular Biosensors To Image Histone Methylation in Living Animals. Anal Chem. 2014 Dec 24. [Epub ahead of print] PubMed PMID: 25506787.

3: Wang L, Chang J, Varghese D, Dellinger M, Kumar S, Best AM, Ruiz J, Bruick R, Peña-Llopis S, Xu J, Babinski DJ, Frantz DE, Brekken RA, Quinn AM, Simeonov A, Easmon J, Martinez ED. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun. 2013;4:2035. doi: 10.1038/ncomms3035. Erratum in: Nat Commun. 2013;4:2639. PubMed PMID: 23792809; PubMed Central PMCID: PMC3724450.



200.0mg / USD 1250.0

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