WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465239
Description: EDMPC is a cationic lipid for RNA and vaccine delivery.
MedKoo Cat#: 465239
Chemical Formula: C39H77F3NO11PS
Exact Mass: 855.4907
Molecular Weight: 856.07
Elemental Analysis: C, 54.72; H, 9.07; F, 6.66; N, 1.64; O, 20.56; P, 3.62; S, 3.75
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
IUPAC/Chemical Name: 2-(((2,3-bis(tetradecanoyloxy)propoxy)(ethoxy)phosphoryl)oxy)-N,N,N-trimethylethan-1-aminium trifluoromethanesulfonate
InChi Key: UQQOUQQAVGUNOE-UHFFFAOYSA-M
InChi Code: InChI=1S/C38H77NO8P.CHF3O3S/c1-7-10-12-14-16-18-20-22-24-26-28-30-37(40)43-34-36(35-46-48(42,44-9-3)45-33-32-39(4,5)6)47-38(41)31-29-27-25-23-21-19-17-15-13-11-8-2;2-1(3,4)8(5,6)7/h36H,7-35H2,1-6H3;(H,5,6,7)/q+1;/p-1
SMILES Code: O=C(CCCCCCCCCCCCC)OC(COP(OCC)(OCC[N+](C)(C)C)=O)COC(CCCCCCCCCCCCC)=O.O=S(C(F)(F)F)([O-])=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 856.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Saunders M, Taylor KM, Craig DQ, Palin K, Robson H. High sensitivity differential scanning calorimetry study of DNA-cationic liposome complexes. Pharm Res. 2007 Oct;24(10):1954-61. doi: 10.1007/s11095-007-9325-1. Epub 2007 Jun 6. PMID: 17551810.
2: Koynova R, MacDonald RC. Lipid transfer between cationic vesicles and lipid- DNA lipoplexes: effect of serum. Biochim Biophys Acta. 2005 Aug 1;1714(1):63-70. doi: 10.1016/j.bbamem.2005.05.009. PMID: 16004959.
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5: Stannard AK, Riddell DR, Bradley NJ, Hassall DG, Graham A, Owen JS. Apolipoprotein E and regulation of cytokine-induced cell adhesion molecule expression in endothelial cells. Atherosclerosis. 1998 Jul;139(1):57-64. doi: 10.1016/s0021-9150(98)00052-5. PMID: 9699892.
6: McDonald RJ, Liggitt HD, Roche L, Nguyen HT, Pearlman R, Raabe OG, Bussey LB, Gorman CM. Aerosol delivery of lipid:DNA complexes to lungs of rhesus monkeys. Pharm Res. 1998 May;15(5):671-9. doi: 10.1023/a:1011902532163. PMID: 9619773.
7: Gorman CM, Aikawa M, Fox B, Fox E, Lapuz C, Michaud B, Nguyen H, Roche E, Sawa T, Wiener-Kronish JP. Efficient in vivo delivery of DNA to pulmonary cells using the novel lipid EDMPC. Gene Ther. 1997 Sep;4(9):983-92. doi: 10.1038/sj.gt.3300473. PMID: 9349436.