EDMPC

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465239

CAS#: unknown

Description: EDMPC is a cationic lipid for RNA and vaccine delivery.


Chemical Structure

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EDMPC
CAS# unknown

Theoretical Analysis

MedKoo Cat#: 465239
Name: EDMPC
CAS#: unknown
Chemical Formula: C39H77F3NO11PS
Exact Mass: 855.4907
Molecular Weight: 856.07
Elemental Analysis: C, 54.72; H, 9.07; F, 6.66; N, 1.64; O, 20.56; P, 3.62; S, 3.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: EDMPC;

IUPAC/Chemical Name: 2-(((2,3-bis(tetradecanoyloxy)propoxy)(ethoxy)phosphoryl)oxy)-N,N,N-trimethylethan-1-aminium trifluoromethanesulfonate

InChi Key: UQQOUQQAVGUNOE-UHFFFAOYSA-M

InChi Code: InChI=1S/C38H77NO8P.CHF3O3S/c1-7-10-12-14-16-18-20-22-24-26-28-30-37(40)43-34-36(35-46-48(42,44-9-3)45-33-32-39(4,5)6)47-38(41)31-29-27-25-23-21-19-17-15-13-11-8-2;2-1(3,4)8(5,6)7/h36H,7-35H2,1-6H3;(H,5,6,7)/q+1;/p-1

SMILES Code: O=C(CCCCCCCCCCCCC)OC(COP(OCC)(OCC[N+](C)(C)C)=O)COC(CCCCCCCCCCCCC)=O.O=S(C(F)(F)F)([O-])=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 856.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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1: Saunders M, Taylor KM, Craig DQ, Palin K, Robson H. High sensitivity differential scanning calorimetry study of DNA-cationic liposome complexes. Pharm Res. 2007 Oct;24(10):1954-61. doi: 10.1007/s11095-007-9325-1. Epub 2007 Jun 6. PMID: 17551810.

2: Koynova R, MacDonald RC. Lipid transfer between cationic vesicles and lipid- DNA lipoplexes: effect of serum. Biochim Biophys Acta. 2005 Aug 1;1714(1):63-70. doi: 10.1016/j.bbamem.2005.05.009. PMID: 16004959.

3: Das A, Niven R. Use of perfluorocarbon (fluorinert) to enhance reporter gene expression following intratracheal instillation into the lungs of Balb/c mice: implications for nebulized delivery of plasmids. J Pharm Sci. 2001 Sep;90(9):1336-44. doi: 10.1002/jps.1086. PMID: 11745786.

4: Noone PG, Hohneker KW, Zhou Z, Johnson LG, Foy C, Gipson C, Jones K, Noah TL, Leigh MW, Schwartzbach C, Efthimiou J, Pearlman R, Boucher RC, Knowles MR. Safety and biological efficacy of a lipid-CFTR complex for gene transfer in the nasal epithelium of adult patients with cystic fibrosis. Mol Ther. 2000 Jan;1(1):105-14. doi: 10.1006/mthe.1999.0009. PMID: 10933918.

5: Stannard AK, Riddell DR, Bradley NJ, Hassall DG, Graham A, Owen JS. Apolipoprotein E and regulation of cytokine-induced cell adhesion molecule expression in endothelial cells. Atherosclerosis. 1998 Jul;139(1):57-64. doi: 10.1016/s0021-9150(98)00052-5. PMID: 9699892.

6: McDonald RJ, Liggitt HD, Roche L, Nguyen HT, Pearlman R, Raabe OG, Bussey LB, Gorman CM. Aerosol delivery of lipid:DNA complexes to lungs of rhesus monkeys. Pharm Res. 1998 May;15(5):671-9. doi: 10.1023/a:1011902532163. PMID: 9619773.

7: Gorman CM, Aikawa M, Fox B, Fox E, Lapuz C, Michaud B, Nguyen H, Roche E, Sawa T, Wiener-Kronish JP. Efficient in vivo delivery of DNA to pulmonary cells using the novel lipid EDMPC. Gene Ther. 1997 Sep;4(9):983-92. doi: 10.1038/sj.gt.3300473. PMID: 9349436.