JH-I-25
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465200

CAS#: 1042673-20-0

Description: JH-I-25 is an IRAK1 kinase inhibitor.


Chemical Structure

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JH-I-25
CAS# 1042673-20-0

Theoretical Analysis

MedKoo Cat#: 465200
Name: JH-I-25
CAS#: 1042673-20-0
Chemical Formula: C20H21N5O3
Exact Mass: 379.1644
Molecular Weight: 379.42
Elemental Analysis: C, 63.31; H, 5.58; N, 18.46; O, 12.65

Price and Availability

Size Price Availability Quantity
5.0mg USD 290.0 2 Weeks
25.0mg USD 750.0 2 Weeks
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Synonym: JH-I-25; JHI-25; JH I-25; JH-I25; JH-I 25; JHI25; JH I 25;

IUPAC/Chemical Name: N-(2-methoxy-4-morpholinophenyl)-6-(1H-pyrazol-5-yl)picolinamide

InChi Key: RAFFLDOJXQAJPF-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H21N5O3/c1-27-19-13-14(25-9-11-28-12-10-25)5-6-17(19)23-20(26)18-4-2-3-15(22-18)16-7-8-21-24-16/h2-8,13H,9-12H2,1H3,(H,21,24)(H,23,26)

SMILES Code: O=C(NC1=CC=C(N2CCOCC2)C=C1OC)C3=NC(C4=CC=NN4)=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 379.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Wang L, Ferrao R, Li Q, Hatcher JM, Choi HG, Buhrlage SJ, Gray NS, Wu H. Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). J Biol Chem. 2019 Mar 22;294(12):4511-4519. doi: 10.1074/jbc.RA118.005428. Epub 2019 Jan 24. PMID: 30679311; PMCID: PMC6433055.

JH-I-25

5.0mg / USD 290.0