WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 333062
CAS#: 950189-66-9 (maleate)
Description: Valacyclovir, also known as valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, being converted in vivo to aciclovir. Valaciclovir has been available as a generic drug in the U.S. since November 25, 2009. Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir (10–20%). It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism. Aciclovir is selectively converted into a monophosphate form by viral thymidine kinase, which is far more effective (3000 times) in phosphorylation of aciclovir than cellular thymidine kinase.
MedKoo Cat#: 333062
Name: Valacyclovir maleate
CAS#: 950189-66-9 (maleate)
Chemical Formula: C17H24N6O8
Exact Mass:
Molecular Weight: 440.413
Elemental Analysis: C, 46.36; H, 5.49; N, 19.08; O, 29.06
Related CAS #: 124832-26-4 (free base) 124832-27-5 (HCl) 950189-66-9 (maleate)
Synonym: 256U87; BW 256; BW-256; BW256; BW-256U87; Valacyclovir; valacyclovir. Val-ACV; Valtrex; Zelitrex; Valacyclovir maleate;
IUPAC/Chemical Name: 2-((2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)ethyl L-valinate maleate
InChi Key: LGBHMEGEVRYKJB-KZDSSNOQSA-N
InChi Code: InChI=1S/C13H20N6O4.C4H4O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20;5-3(6)1-2-4(7)8/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20);1-2H,(H,5,6)(H,7,8)/b;2-1-/t8-;/m0./s1
SMILES Code: O=C(O)/C=C\C(O)=O.N[C@@H](C(C)C)C(OCCOCN1C=NC2=C1N=C(N)NC2=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 440.413 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
