UJN49930
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MedKoo CAT#: 464827

CAS#: 2414349-93-0

Description: UJN49930 is an inhibitor of UDP-galactose ceramide galactosyltransferase (UGT8), also known as ceramide galactosyltranferase (CGT; IC50 = 0.2 nM).1 It is selective for UGT8 over UGT1A1, -1A6, -2B7, -2B15, and -2B17 (IC50s = >10 µM for all). In vivo, UJN49930 inhibits the synthesis of galactosylceramide (GalCer) and sulfatide (SFT) in juvenile mouse brain (ED50s = <3 mg/kg for both) and adult mouse kidney when administered at doses of 3, 10, and 30 mg/kg.


Chemical Structure

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UJN49930
CAS# 2414349-93-0

Theoretical Analysis

MedKoo Cat#: 464827
Name: UJN49930
CAS#: 2414349-93-0
Chemical Formula: C20H22F6N4O4S
Exact Mass: 528.1266
Molecular Weight: 528.4704
Elemental Analysis: C, 45.46; H, 4.20; F, 21.57; N, 10.60; O, 12.11; S, 6.07

Price and Availability

Size Price Availability Quantity
5.0mg USD 425.0 2 Weeks
10.0mg USD 815.0 2 Weeks
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Synonym: UJN49930; UJN 49930; UJN-49930; UGT8 Inhibitor 19; Ceramide Galactosyltransferase Inhibitor 19; CGT Inhibitor 19; UDP-galactose Ceramide Galactosyltransferase Inhibitor 19;

IUPAC/Chemical Name: 1-(3-(methylcarbamoyl)-7-(trifluoromethyl)thieno[3,2-b]pyridin-5-yl)piperidin-4-yl (S)-(1-(trifluoromethoxy)propan-2-yl)carbamate

InChi Key: UQQUABVWYAPTIQ-JTQLQIEISA-N

InChi Code: InChI=1S/C20H22F6N4O4S/c1-10(8-33-20(24,25)26)28-18(32)34-11-3-5-30(6-4-11)14-7-13(19(21,22)23)16-15(29-14)12(9-35-16)17(31)27-2/h7,9-11H,3-6,8H2,1-2H3,(H,27,31)(H,28,32)/t10-/m0/s1

SMILES Code: CNC(C1=CSC2=C(C(F)(F)F)C=C(N3CCC(OC(N[C@H](COC(F)(F)F)C)=O)CC3)N=C12)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 30.0 56.77
DMSO 30.0 56.77
Ethanol 25.0 47.31

Preparing Stock Solutions

The following data is based on the product molecular weight 528.4704 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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