ALC-0315
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MedKoo CAT#: 556006

CAS#: 2036272-55-4

Description: ALC-0315 is a synthetic cationic lipid (or ionizable lipid). It is a colorless oily material, It has attracted attention as a component of the SARS-CoV-2 vaccine, BNT162b2, from BioNTech and Pfizer. Specifically, it is one of four components that form lipid nanoparticles (LNPs), which encapsulate and protect the otherwise fragile mRNA that is the active ingredient in these drugs. These nanoparticles promote the uptake of therapeutically effective nucleic acids such as oligonucleotides or mRNA both in vitro and in vivo. At physiological pH, ALC-0315 becomes protonated at the nitrogen atom, yielding an ammonium cation that is attracted to the messenger RNA (mRNA), which is anionic. (https://en.wikipedia.org/wiki/ALC-0315)


Chemical Structure

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ALC-0315
CAS# 2036272-55-4

Theoretical Analysis

MedKoo Cat#: 556006
Name: ALC-0315
CAS#: 2036272-55-4
Chemical Formula: C48H95NO5
Exact Mass: 765.721
Molecular Weight: 766.29
Elemental Analysis: C, 75.24; H, 12.50; N, 1.83; O, 10.44

Price and Availability

Size Price Availability Quantity
10.0mg USD 175.0 Ready to ship
25.0mg USD 392.0 Ready to ship
50.0mg USD 705.0 Ready to ship
100.0mg USD 1250.0 Ready to ship
200.0mg USD 1950.0 Ready to ship
500.0mg USD 2950.0 Ready to ship
1.0g USD 3650.0 Ready to ship
2.0g USD 5950.0 Ready to ship
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Synonym: ALC-0315; ALC 0315; ALC0315;

IUPAC/Chemical Name: [(4-Hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate)

InChi Key: QGWBEETXHOVFQS-UHFFFAOYSA-N

InChi Code: InChI=1S/C48H95NO5/c1-5-9-13-17-19-27-37-45(35-25-15-11-7-3)47(51)53-43-33-23-21-29-39-49(41-31-32-42-50)40-30-22-24-34-44-54-48(52)46(36-26-16-12-8-4)38-28-20-18-14-10-6-2/h45-46,50H,5-44H2,1-4H3

SMILES Code: OCCCCN(CCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCOC(C(CCCCCC)CCCCCCCC)=O

Appearance: Colorless to light yellow oily liquid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Chloroform (50mg/mL) and ethanol (100mg/mL)

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Biological target: ALC-0315 is a synthetic cationic lipid (or ionizable lipid).
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
chloroform 50.0 65.25
ethanol 100.0 130.51
DMSO 50.0 65.25

Preparing Stock Solutions

The following data is based on the product molecular weight 766.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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Moghimi SM. Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines. Mol Ther. 2021 Mar 3;29(3):898-900. doi: 10.1016/j.ymthe.2021.01.030. Epub 2021 Feb 5. PMID: 33571463; PMCID: PMC7862013.

ALC-0315

10.0mg / USD 175.0