CFI-400437 HCl
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MedKoo CAT#: 408157

CAS#: 1247000-76-5 (HCl)

Description: CFI-400437 is a potent and selective inhibitor of polo-like kinase 4 (PLK4). The family of Polo-like kinases is important in the regulation of mitotic progression; this work keys on one member, namely Polo-like kinase 4 (PLK4). PLK4 has been identified as a candidate anticancer target which prompted a search for potent and selective inhibitors of PLK4.


Chemical Structure

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CFI-400437 HCl
CAS# 1247000-76-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 408157
Name: CFI-400437 HCl
CAS#: 1247000-76-5 (HCl)
Chemical Formula: C29H30Cl2N6O2
Exact Mass:
Molecular Weight: 565.5
Elemental Analysis: C, 61.59; H, 5.35; Cl, 12.54; N, 14.86; O, 5.66

Price and Availability

Size Price Availability Quantity
200.0mg USD 3250.0 2 Weeks
500.0mg USD 4950.0 2 Weeks
1.0g USD 5950.0 2 Weeks
2.0g USD 8950.0 2 Weeks
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Related CAS #: 1169211-37-3 (free base)   1247000-76-5 (HCl)    

Synonym: CFI-400437 HCl, CFI-400437 hydrochloride; CFI-400437 dihydrochloride; CFI-400437; CFI 400437;

IUPAC/Chemical Name: 5-Methoxy-3-(3-{2-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-vinyl}-1H-indazol-6-ylmethylene)-1,3-dihydro-indol-2-one dihydrochloride

InChi Key: XQZOWXHJNLSRCM-FFJVXDJSSA-N

InChi Code: InChI=1S/C29H28N6O2.2ClH/c1-34-11-13-35(14-12-34)28-10-5-19(18-30-28)4-8-26-22-7-3-20(16-27(22)33-32-26)15-24-23-17-21(37-2)6-9-25(23)31-29(24)36;;/h3-10,15-18H,11-14H2,1-2H3,(H,31,36)(H,32,33);2*1H/b8-4+,24-15-;;

SMILES Code: CN1CCN(C2=NC=C(/C=C/C3=NNC4=C3C=CC(/C=C5C6=C(NC/5=O)C=CC(OC)=C6)=C4)C=C2)CC1.Cl.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 565.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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