L-163491

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414281

CAS#: 170969-73-0

Description: L-163491 is a drug which acts as a partial agonist of angiotensin II receptor type 1, and with lower affinity as an agonist of angiotensin II receptor type 2, mimicking the action of angiotensin II. Its practical applications to date have been limited to scientific research into the function of the angiotensin receptor system, but it has been suggested as a potential therapeutic agent for the treatment of inflammation of the lungs associated with certain viral diseases such as COVID-19.

Chemical Structure

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L-163491
CAS# 170969-73-0
Instruction

Theoretical Analysis

MedKoo Cat#: 414281
Name: L-163491
CAS#: 170969-73-0
Chemical Formula: C36H40N4O5S
Exact Mass: 640.27
Molecular Weight: 640.790
Elemental Analysis: C, 67.48; H, 6.29; N, 8.74; O, 12.48; S, 5.00

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: L-163491; L163491; L 163491

IUPAC/Chemical Name: 5,7-Dimethyl-2-ethyl-3-((2'-((butyloxycarbonyl) aminosulfonyl)-5'-(3-methyoxybenzyl)-(1,1'-biphenyl)-4-yl)methyl)-3H-imidazo(4,5-b)pyridine

InChi Key: SRCIRAKBWHTYIX-UHFFFAOYSA-N

InChi Code: InChI=1S/C36H40N4O5S/c1-6-8-18-45-36(41)39-46(42,43)32-17-14-28(20-27-10-9-11-30(21-27)44-5)22-31(32)29-15-12-26(13-16-29)23-40-33(7-2)38-34-24(3)19-25(4)37-35(34)40/h9-17,19,21-22H,6-8,18,20,23H2,1-5H3,(H,39,41)

SMILES Code: COC1=CC(CC2=CC=C(S(=O)(NC(OCCCC)=O)=O)C(C3=CC=C(CN4C(CC)=NC5=C(C)C=C(C)N=C54)C=C3)=C2)=CC=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 640.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: De Witt BJ, Garrison EA, Champion HC, Kadowitz PJ. L-163,491 is a partial angiotensin AT(1) receptor agonist in the hindquarters vascular bed of the cat. Eur J Pharmacol. 2000 Sep 15;404(1-2):213-9. doi: 10.1016/s0014-2999(00)00612-9. PMID: 10980281.


2: Kaye AD, Nossaman BD, Kivlighn S, Ibrahim IN, De Witt BJ, Kadowitz PJ. Responses to L-163,491, a nonpeptide angiotensin II mimic, in the pulmonary vascular bed of the cat. Eur J Pharmacol. 1995 Dec 12;287(2):163-8. doi: 10.1016/0014-2999(95)00486-6. PMID: 8749030.


3: Kaye AD, Nossaman BD, Margolis MA, Ibrahim IN, Kivlighn SD, Smith DE, Kadowitz PJ. Responses to a nonpeptide angiotensin receptor agonist, L 163491, in the feline pulmonary vascular bed. Life Sci. 1995;57(20):PL301-5. doi: 10.1016/0024-3205(95)02169-j. PMID: 7475924.