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MedKoo CAT#: 510283

CAS#: 1235481-90-9 (free base)

Description: P7C3-A20 is an analogue of P7C3, and is a proneurogenic, neuroprotective agent. P7C3-A20 displayed increased activity and an improved toxicity profile compared to P7C3. P7C3-A20 demonstrated greater proneurogenic efficacy than a wide spectrum of currently marketed antidepressant drugs. P7C3-A20 showed neuroprotective properties in rodent models of Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury and age-related cognitive decline.

Price and Availability

Size Price Shipping out time Quantity
25mg USD 110 Same day
50mg USD 190 Same day
100mg USD 350 Same day
200mg USD 630 Same day
500mg USD 1350 Same day
1g USD 2450 Same day
2g USD 4350 Same day
5g USD 7850 2 weeks
Inquire bulk and customized quantity

Pricing updated 2020-05-29. Prices are subject to change without notice.

P7C3-A20, purity > 98%, is in stock. The same day shipping out after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 510283
Name: P7C3-A20
CAS#: 1235481-90-9 (free base)
Chemical Formula: C22H19Br2FN2O
Exact Mass: 503.98482
Molecular Weight: 506.21
Elemental Analysis: C, 52.20; H, 3.78; Br, 31.57; F, 3.75; N, 5.53; O, 3.16

Related CAS #: 1235481-90-9 (free base)   1485572-67-5 (HCl)    

Synonym: P7C3-A20; P7C3A20; P7C3 A20

IUPAC/Chemical Name: N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-3-methoxyaniline


InChi Code: InChI=1S/C22H19Br2FN2O/c1-28-18-4-2-3-17(11-18)26-12-16(25)13-27-21-7-5-14(23)9-19(21)20-10-15(24)6-8-22(20)27/h2-11,16,26H,12-13H2,1H3

SMILES Code: COC1=CC(NCC(F)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3)=CC=C1

Technical Data

Light yellow solid to semi-solid powder

>98% (or refer to the Certificate of Analysis)

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
1. Literature method: P7C3A20 were dissolved in 5% dextrose (pH 7.0) with 2.5% DMSO and 10% Cremaphor EL (Sigma; C5135). (Ref: Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17010-5). 2. This drug may be formulated in DMSO 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information

Related CAS#
CAS#1235481-90-9 (P7C3-A20 free);
CAS#1485572-67-5 (P7C3-A20 HCl salt)


1: Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis. Mol Psychiatry. 2014 Apr 22. doi: 10.1038/mp.2014.34. [Epub ahead of print] PubMed PMID: 24751964.

2: Pieper AA, McKnight SL, Ready JM. P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases. Chem Soc Rev. 2014 Feb 11. [Epub ahead of print] PubMed PMID: 24514864.

3: Blaya MO, Bramlett HM, Naidoo J, Pieper AA, Dietrich WD. Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury. J Neurotrauma. 2014 Mar 1;31(5):476-86. doi: 10.1089/neu.2013.3135. Epub 2013 Dec 19. PubMed PMID: 24070637; PubMed Central PMCID: PMC3934600.