Ketoprofen sodium

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MedKoo CAT#: 414229

CAS#: 57495-14-4 (Na)

Description: Ketoprofen sodium is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.


Chemical Structure

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Ketoprofen sodium
CAS# 57495-14-4 (Na)

Theoretical Analysis

MedKoo Cat#: 414229
Name: Ketoprofen sodium
CAS#: 57495-14-4 (Na)
Chemical Formula: C16H13NaO3
Exact Mass: 276.08
Molecular Weight: 276.270
Elemental Analysis: C, 69.56; H, 4.74; Na, 8.32; O, 17.37

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 57469-78-0 ( lysine salt)   22071-15-4 (free base)   76690-94-3 (glucuronide)   57495-14-4 (Na)  

Synonym: Ketoprofen sodium; 19583 RP-Na; 19583-RP-Na; 19583RP-Na

IUPAC/Chemical Name: Benzeneacetic acid, 3-benzoyl-alpha-methyl-, sodium salt

InChi Key: OAPDLBHLMVYMCW-UHFFFAOYSA-M

InChi Code: InChI=1S/C16H14O3.Na/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12;/h2-11H,1H3,(H,18,19);/q;+1/p-1

SMILES Code: O=C([O-])C(C)C1=CC=CC(C(C2=CC=CC=C2)=O)=C1.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 276.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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7: Kokki H. Ketoprofen pharmacokinetics, efficacy, and tolerability in pediatric patients. Paediatr Drugs. 2010 Oct 1;12(5):313-29. doi: 10.2165/11534910-000000000-00000. Review. PubMed PMID: 20799760.

8: Sarzi-Puttini P, Atzeni F, Lanata L, Bagnasco M, Colombo M, Fischer F, D'Imporzano M. Pain and ketoprofen: what is its role in clinical practice? Reumatismo. 2010 Jul-Sep;62(3):172-88. Review. PubMed PMID: 21052564.

9: Cantisani C, Grieco T, Faina V, Mattozzi C, Bohnenberger H, Silvestri E, Calvieri S. Ketoprofen allergic reactions. Recent Pat Inflamm Allergy Drug Discov. 2010 Jan;4(1):58-64. Review. PubMed PMID: 19832694.

10: Barden J, Derry S, McQuay HJ, Moore RA. Single dose oral ketoprofen and dexketoprofen for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007355. doi: 10.1002/14651858.CD007355.pub2. Review. PubMed PMID: 19821407; PubMed Central PMCID: PMC4171124.

11: Mazières B. Topical ketoprofen patch. Drugs R D. 2005;6(6):337-44. Review. PubMed PMID: 16274258.

12: Mullangi R, Yao M, Srinivas NR. Resolution of enantiomers of ketoprofen by HPLC: a review. Biomed Chromatogr. 2003 Oct;17(7):423-34. Review. PubMed PMID: 14598325.

13: Veyrac G, Paulin M, Milpied B, Bourin M, Jolliet P. [Results of a French nationwide survey of cutaneous side effects of ketoprofen gel reported between September 1996 and August 2000]. Therapie. 2002 Jan-Feb;57(1):55-64. Review. French. PubMed PMID: 12090148.

14: Ouchi A, Zandomeneghi G, Zandomeneghi M. Complexation with albumins of chiral aromatic substrates and their chemistry in ground and excited states. Catalytic and chirality recognition properties of the protein in the cases of binaphthol, its photoisomers, and ketoprofen. Chirality. 2002 Jan;14(1):1-11. Review. PubMed PMID: 11748793.

15: Sugiura M, Hayakawa R, Kato Y, Sugiura K, Ueda H. 4 cases of photocontact dermatitis due to ketoprofen. Contact Dermatitis. 2000 Jul;43(1):16-9. Review. PubMed PMID: 10902583.

16: Schumacher HR Jr. Ketoprofen extended-release capsules: a new formulation for the treatment of osteoarthritis and rheumatoid arthritis. Clin Ther. 1994 Mar-Apr;16(2):145-59. Review. PubMed PMID: 8062310.

17: Serrano G, Fortea JM, Latasa JM, Millan F, Janes C, Bosca F, Miranda MA. Photosensitivity induced by fibric acid derivatives and its relation to photocontact dermatitis to ketoprofen. J Am Acad Dermatol. 1992 Aug;27(2 Pt 1):204-8. Review. PubMed PMID: 1430357.

18: Jamali F, Brocks DR. Clinical pharmacokinetics of ketoprofen and its enantiomers. Clin Pharmacokinet. 1990 Sep;19(3):197-217. Review. PubMed PMID: 2203580.

19: Sunshine A, Olson NZ. Analgesic efficacy of ketoprofen in postpartum, general surgery, and chronic cancer pain. J Clin Pharmacol. 1988 Dec;28(12 Suppl):S47-54. Review. PubMed PMID: 3072358.

20: Williams RL, Upton RA. The clinical pharmacology of ketoprofen. J Clin Pharmacol. 1988 Dec;28(12 Suppl):S13-22. Review. PubMed PMID: 3072352.