KB 5246

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414210

CAS#: 119474-55-4

Description: KB 5246 is a tetracyclic quinolone and displays antibacterial activities.

Chemical Structure

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KB 5246
CAS# 119474-55-4
Instruction

Theoretical Analysis

MedKoo Cat#: 414210
Name: KB 5246
CAS#: 119474-55-4
Chemical Formula: C18H17ClFN3O4S
Exact Mass: 425.06
Molecular Weight: 425.860
Elemental Analysis: C, 50.77; H, 4.02; Cl, 8.32; F, 4.46; N, 9.87; O, 15.03; S, 7.53

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: KB 5246; KB-5246; KB5246

IUPAC/Chemical Name: 3H,8H-4-Oxa-1-thia-9b-azacyclopenta(cd)phenalene-9-carboxylic acid, 6-fluoro-5-(4-methyl-1-piperazinyl)-8-oxo-, monohydrochloride

InChi Key: DCZBGPOFHPVYER-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H16FN3O4S.ClH/c1-20-2-4-21(5-3-20)14-11(19)6-10-13-12-9(7-26-15(13)14)8-27-17(12)22(16(10)23)18(24)25;/h6,8H,2-5,7H2,1H3,(H,24,25);1H

SMILES Code: O=C(N(C1=O)C2=C3C(COC4=C3C1=CC(F)=C4N5CCN(C)CC5)=CS2)O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 425.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kotera Y, Mitsuhashi S. In vitro and in vivo antibacterial activities of KB-5246, a new tetracyclic quinolone. Antimicrob Agents Chemother. 1989 Nov;33(11):1896-900. doi: 10.1128/AAC.33.11.1896. PMID: 2610501; PMCID: PMC172784.

2: Kotera Y, Inoue M, Mitsuhashi S. Activity of KB-5246 against outer membrane mutants of Escherichia coli and Salmonella typhimurium. Antimicrob Agents Chemother. 1990 Jul;34(7):1323-5. doi: 10.1128/AAC.34.7.1323. PMID: 2167038; PMCID: PMC175974.

3: Kotera Y, Inoue Y, Ohashi M, Ito K, Inoue M. Lack of effect of carbonyl cyanide m-chlorophenylhydrazone on KB-5246 accumulation by Staphylococcus aureus. Antimicrob Agents Chemother. 1992 Apr;36(4):883-5. doi: 10.1128/AAC.36.4.883. PMID: 1323957; PMCID: PMC189480.

4: Nakanishi N, Kojima T, Fujimoto T, Mitsuhashi S. In vitro properties of the newer quinolones. Prog Drug Res. 1992;38:19-28. PMID: 1609115.

5: Chu DT, Lico IM, Claiborne AK, Plattner JJ, Pernet AG. Structure-activity relationship of quinolone antibacterial agents: the effects of C-2 substitution. Drugs Exp Clin Res. 1990;16(5):215-24. PMID: 1964116.

6: Kotera Y, Inoue Y, Ohashi M, Ito K, Tsukamoto G. Antibacterial activity of a new tetracyclic quinolone, No. 5290, against norfloxacin- and ciprofloxacin- resistant strains of Staphylococcus aureus. Chem Pharm Bull (Tokyo). 1991 Oct;39(10):2644-6. doi: 10.1248/cpb.39.2644. PMID: 1666861.