K201 free base

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MedKoo CAT#: 414202

CAS#: 145903-06-6 (free base)

Description: K201 free base is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties.

Chemical Structure

K201 free base
CAS# 145903-06-6 (free base)

Theoretical Analysis

MedKoo Cat#: 414202
Name: K201 free base
CAS#: 145903-06-6 (free base)
Chemical Formula: C25H32N2O2S
Exact Mass: 424.2184
Molecular Weight: 424.6
Elemental Analysis: C, 70.72; H, 7.60; N, 6.60; O, 7.54; S, 7.55

Price and Availability

Size Price Availability Quantity
5.0mg USD 288.0 2 Weeks
25.0mg USD 705.0 2 Weeks
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Related CAS #: 145903-06-6 (free base)   1038410-88-6 (HCl)  

Synonym: K201 free base; K 201 free base; K-201 free base

IUPAC/Chemical Name: 3-(4-benzylpiperidin-1-yl)-1-(7-methoxy-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)propan-1-one


InChi Code: InChI=1S/C25H32N2O2S/c1-29-23-7-8-24-22(18-23)19-27(15-16-30-24)25(28)11-14-26-12-9-21(10-13-26)17-20-5-3-2-4-6-20/h2-8,18,21H,9-17,19H2,1H3

SMILES Code: COc1cc2c(SCCN(C(CCN3CCC(CC3)Cc4ccccc4)=O)C2)cc1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 424.6 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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