WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 414192
CAS#: 90581-63-8
Description: Falintolol is a beta-adrenergic receptor antagonist.
MedKoo Cat#: 414192
Name: Falintolol
CAS#: 90581-63-8
Chemical Formula: C12H24N2O2
Exact Mass: 228.1838
Molecular Weight: 228.34
Elemental Analysis: C, 63.12; H, 10.59; N, 12.27; O, 14.01
This product is not in stock, which may be available by custom synthesis.
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Synonym: Falintolol; Falintololum
IUPAC/Chemical Name: (E)-1-cyclopropylethan-1-one O-(3-(tert-butylamino)-2-hydroxypropyl) oxime
InChi Key: IYQDIWRBEQWANY-NTEUORMPSA-N
InChi Code: InChI=1S/C12H24N2O2/c1-9(10-5-6-10)14-16-8-11(15)7-13-12(2,3)4/h10-11,13,15H,5-8H2,1-4H3/b14-9+
SMILES Code: C/C(C1CC1)=N\OCC(CNC(C)(C)C)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 228.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Andermann G, Guggenbuhl P, de Burlet G, Himber J. Pharmacokinetics of falintolol II. Absorption, distribution and elimination from tissues and organs following ocular administration and intravenous injection of falintolol in albino rabbits. Methods Find Exp Clin Pharmacol. 1989 Dec;11(12):747-54. PMID: 2576299.
2: Himber J, Andermann G, Bouzoubaa M, Leclerc G. Determination of falintolol, a new aliphatic beta-adrenergic antagonist, in whole blood by gas chromatography with electron-capture detection: geometric isomers resolution. J Chromatogr Sci. 1987 Jan;25(1):33-7. doi: 10.1093/chromsci/25.1.33. PMID: 2880859.
3: Himber J, Sallee VL, Andermann G, Bouzoubaa M, Leclerc G, De Santis L. Effects of topically applied falintolol: a new beta-adrenergic antagonist for treatment of glaucoma. J Ocul Pharmacol. 1987 Summer;3(2):111-20. doi: 10.1089/jop.1987.3.111. PMID: 2903204.
4: Himber J, Andermann G, Erhart M, Leclerc G, Bouzoubaa M. In vitro potential measurement, anaesthetic and antimicrobial effects as indicators of beta-blocker toxicity of the cornea. Methods Find Exp Clin Pharmacol. 1985 Apr;7(4):195-201. PMID: 2862314.
5: Conti P, Dallanoce C, De Amici M, De Micheli C, Klotz KN. Synthesis of new delta 2-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists. Bioorg Med Chem. 1998 Apr;6(4):401-8. doi: 10.1016/s0968-0896(97)10051-7. PMID: 9597184.
6: Bouzoubaa M, Leclerc G, Rakhit S, Andermann G. New chiral and isomeric cyclopropyl ketoxime propanolamine derivatives with potent beta-adrenergic blocking properties. J Med Chem. 1985 Jul;28(7):896-900. doi: 10.1021/jm00145a008. PMID: 2861288.
