Falintolol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414192

CAS#: 90581-63-8

Description: Falintolol is a beta-adrenergic receptor antagonist.


Chemical Structure

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Falintolol
CAS# 90581-63-8

Theoretical Analysis

MedKoo Cat#: 414192
Name: Falintolol
CAS#: 90581-63-8
Chemical Formula: C12H24N2O2
Exact Mass: 228.1838
Molecular Weight: 228.34
Elemental Analysis: C, 63.12; H, 10.59; N, 12.27; O, 14.01

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Falintolol; Falintololum

IUPAC/Chemical Name: (E)-1-cyclopropylethan-1-one O-(3-(tert-butylamino)-2-hydroxypropyl) oxime

InChi Key: IYQDIWRBEQWANY-NTEUORMPSA-N

InChi Code: InChI=1S/C12H24N2O2/c1-9(10-5-6-10)14-16-8-11(15)7-13-12(2,3)4/h10-11,13,15H,5-8H2,1-4H3/b14-9+

SMILES Code: C/C(C1CC1)=N\OCC(CNC(C)(C)C)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 228.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Andermann G, Guggenbuhl P, de Burlet G, Himber J. Pharmacokinetics of falintolol II. Absorption, distribution and elimination from tissues and organs following ocular administration and intravenous injection of falintolol in albino rabbits. Methods Find Exp Clin Pharmacol. 1989 Dec;11(12):747-54. PMID: 2576299.

2: Himber J, Andermann G, Bouzoubaa M, Leclerc G. Determination of falintolol, a new aliphatic beta-adrenergic antagonist, in whole blood by gas chromatography with electron-capture detection: geometric isomers resolution. J Chromatogr Sci. 1987 Jan;25(1):33-7. doi: 10.1093/chromsci/25.1.33. PMID: 2880859.

3: Himber J, Sallee VL, Andermann G, Bouzoubaa M, Leclerc G, De Santis L. Effects of topically applied falintolol: a new beta-adrenergic antagonist for treatment of glaucoma. J Ocul Pharmacol. 1987 Summer;3(2):111-20. doi: 10.1089/jop.1987.3.111. PMID: 2903204.

4: Himber J, Andermann G, Erhart M, Leclerc G, Bouzoubaa M. In vitro potential measurement, anaesthetic and antimicrobial effects as indicators of beta-blocker toxicity of the cornea. Methods Find Exp Clin Pharmacol. 1985 Apr;7(4):195-201. PMID: 2862314.

5: Conti P, Dallanoce C, De Amici M, De Micheli C, Klotz KN. Synthesis of new delta 2-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists. Bioorg Med Chem. 1998 Apr;6(4):401-8. doi: 10.1016/s0968-0896(97)10051-7. PMID: 9597184.

6: Bouzoubaa M, Leclerc G, Rakhit S, Andermann G. New chiral and isomeric cyclopropyl ketoxime propanolamine derivatives with potent beta-adrenergic blocking properties. J Med Chem. 1985 Jul;28(7):896-900. doi: 10.1021/jm00145a008. PMID: 2861288.