(S,R,S)-AHPC-Me
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MedKoo CAT#: 408156

CAS#: 1948273-02-6

Description: (S,R,S)-AHPC-Me is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a BET PROTAC degrader.


Chemical Structure

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(S,R,S)-AHPC-Me
CAS# 1948273-02-6

Theoretical Analysis

MedKoo Cat#: 408156
Name: (S,R,S)-AHPC-Me
CAS#: 1948273-02-6
Chemical Formula: C23H32N4O3S
Exact Mass: 444.2195
Molecular Weight: 444.594
Elemental Analysis: C, 62.14; H, 7.26; N, 12.60; O, 10.80; S, 7.21

Price and Availability

Size Price Availability Quantity
500.0mg USD 1250.0 2 Weeks
1.0g USD 2250.0 2 Weeks
2.0g USD 3450.0 2 Weeks
5.0g USD 4950.0 2 Weeks
10.0g USD 6950.0 2 Weeks
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Related CAS #: 1948273-02-6  

Synonym: (S,R,S)-AHPC-Me; VHL ligand 2; E3 ligase Ligand 1A

IUPAC/Chemical Name: (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

InChi Key: JOSFQWNOUSNZBP-UUZHKXTQSA-N

InChi Code: InChI=1S/C23H32N4O3S/c1-13(15-6-8-16(9-7-15)19-14(2)25-12-31-19)26-21(29)18-10-17(28)11-27(18)22(30)20(24)23(3,4)5/h6-9,12-13,17-18,20,28H,10-11,24H2,1-5H3,(H,26,29)/t13-,17+,18-,20+/m0/s1

SMILES Code: N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 444.594 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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