Exeporfinium bromide | CAS#943326-71-4 | antibacterial

Exeporfinium bromide
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414172

CAS#: 943326-71-4 (bromide)

Description: Exeporfinium, also known as XF-73, is an anti-microbial which works via weakening bacteria cell walls. Exeporfinium chloride is a potential treatment for methicillin-resistant Staphylococcus aureus (MRSA) and possibly Clostridium difficile. Exeporfinium chloride has completed a phase I clinical trial for nasal decolonisation of MRSA—being tested against 5 bacterial strains. It seems unlikely to cause MRSA to develop resistance to it. Structurally it is a dicationic porphyrin.

Chemical Structure

Exeporfinium bromide

CAS# 943326-71-4 (bromide)

Instruction

Theoretical Analysis

MedKoo Cat#: 414172
Name: Exeporfinium bromide
CAS#: 943326-71-4 (bromide)
Chemical Formula: C44H50Br2N6O2
Exact Mass: 694.40
Molecular Weight: 854.730
Elemental Analysis: C, 61.83; H, 5.90; Br, 18.70; N, 9.83; O, 3.74

Price and Availability

Size	Price	Availability
1mg	USD 150	Ready to ship
5mg	USD 450	Ready to ship
10mg	USD 750	Ready to ship
25mg	USD 1650	Ready to ship
50mg	USD 2650	Ready to ship
100mg	USD 4650	Ready to ship
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 756818-36-7 (cation) 718638-68-7 (Cl) 943326-71-4 (bromide)

Synonym: XF-73; XF 73; XF73; Exeporfinium bromide

IUPAC/Chemical Name: 3,3'-((porphyrin-5,15-diylbis(4,1-phenylene))bis(oxy))bis(N,N,N-trimethylpropan-1-aminium) dibromide

InChi Key: OOOQIWWDNZLZQQ-XRFOENPRSA-L

InChi Code: InChI=1S/C44H50N6O2.2BrH/c1-49(2,3)25-7-27-51-37-17-9-31(10-18-37)43-39-21-13-33(45-39)29-35-15-23-41(47-35)44(42-24-16-36(48-42)30-34-14-22-40(43)46-34)32-11-19-38(20-12-32)52-28-8-26-50(4,5)6;;/h9-24,29-30,45,48H,7-8,25-28H2,1-6H3;2*1H/q+2;;/p-2/b33-29-,34-30-,35-29-,36-30-,43-39-,43-40-,44-41-,44-42-;;

SMILES Code: C[N+](C)(C)CCCOC1=CC=C(/C2=C3C=CC(/C=C4C=C/C(N/4)=C(C5=CC=C(OCCC[N+](C)(C)C)C=C5)/C(C=C/6)=NC6=C/C7=CC=C2N7)=N\3)C=C1.[Br-].[Br-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Certificate of Analysis:

View CoA: current batch, Lot# YXM211028

QC Data:

View QC data: current batch, Lot# YXM211028

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 854.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gonzales FP, Felgenträger A, Bäumler W, Maisch T. Fungicidal photodynamic effect of a twofold positively charged porphyrin against Candida albicans planktonic cells and biofilms. Future Microbiol. 2013 Jun;8(6):785-97. doi: 10.2217/fmb.13.44. PubMed PMID: 23701333.

2: Farrell DJ, Robbins M, Rhys-Williams W, Love WG. Investigation of the potential for mutational resistance to XF-73, retapamulin, mupirocin, fusidic acid, daptomycin, and vancomycin in methicillin-resistant Staphylococcus aureus isolates during a 55-passage study. Antimicrob Agents Chemother. 2011 Mar;55(3):1177-81. doi: 10.1128/AAC.01285-10. Epub 2010 Dec 13. PubMed PMID: 21149626; PubMed Central PMCID: PMC3067113.

3: Walker K. Interscience Conference on Antimicrobial Agents and Chemotherapy - 50th Annual Meeting - Research on Promising New Agents: Part 1. IDrugs. 2010 Nov;13(11):743-5. PubMed PMID: 21046515.

4: Schmitz J, Holzgrabe U. [XF-73 - a new antibacterial lead compound]. Pharm Unserer Zeit. 2010 Sep;39(5):335-6. doi: 10.1002/pauz.201090075. German. PubMed PMID: 20818680.

5: Farrell DJ, Robbins M, Rhys-Williams W, Love WG. In vitro activity of XF-73, a novel antibacterial agent, against antibiotic-sensitive and -resistant Gram-positive and Gram-negative bacterial species. Int J Antimicrob Agents. 2010 Jun;35(6):531-6. doi: 10.1016/j.ijantimicag.2010.02.008. Epub 2010 Mar 25. PubMed PMID: 20346634.

6: Ooi N, Miller K, Randall C, Rhys-Williams W, Love W, Chopra I. XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms. J Antimicrob Chemother. 2010 Jan;65(1):72-8. doi: 10.1093/jac/dkp409. Epub . PubMed PMID: 19889790.

7: Ooi N, Miller K, Hobbs J, Rhys-Williams W, Love W, Chopra I. XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity. J Antimicrob Chemother. 2009 Oct;64(4):735-40. doi: 10.1093/jac/dkp299. Epub 2009 Aug 18. PubMed PMID: 19689976.

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