WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 111528
CAS#: 2646-71-1 (sodium)
Description: NADPH, tetrasodium salt is the sodium salt form of NADPH, which the reduced form of NADP+. NADPH is used in anabolic reactions (such as lipid and nucleic acid synthesis) as a reducing agent and cofactor.
MedKoo Cat#: 111528
Name: NADPH tetrasodium
CAS#: 2646-71-1 (sodium)
Chemical Formula: C21H26N7Na4O17P3
Exact Mass:
Molecular Weight: 833.35
Elemental Analysis: C, 30.27; H, 3.14; N, 11.77; Na, 11.03; O, 32.64; P, 11.15
Related CAS #: 53-57-6 (free acid) 604-79-5 (oxidized) 2646-71-1 (sodium) 100929-71-3 (ammonium) 100929-71-3 (Cy4N)
Synonym: Dihydronicotinamide-adenine dinucleotide phosphate, tetrasodium salt; NADPH sodium salt
IUPAC/Chemical Name: sodium (2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-((((((((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1(4H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)oxidophosphoryl)oxy)oxidophosphoryl)oxy)methyl)-4-hydroxytetrahydrofuran-3-yl phosphate
InChi Key: WYWWVJHQDVCHKF-ITGWJZMWSA-J
InChi Code: InChI=1S/C21H30N7O17P3.4Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;;;/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35);;;;/q;4*+1/p-4/t10-,11-,13-,14-,15-,16-,20-,21-;;;;/m1..../s1
SMILES Code: O=P([O-])([O-])O[C@H]1[C@H](N2C=NC3=C(N)N=CN=C23)O[C@H](COP([O-])(OP([O-])(OC[C@H]4O[C@@H](N5C=CCC(C(N)=O)=C5)[C@H](O)[C@@H]4O)=O)=O)[C@H]1O.[Na+].[Na+].[Na+].[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 833.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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11: Zhu X, Kalyanaraman N, Subramanian R. Enhanced screening of glutathione- trapped reactive metabolites by in-source collision-induced dissociation and extraction of product ion using UHPLC-high resolution mass spectrometry. Anal Chem. 2011 Dec 15;83(24):9516-23. doi: 10.1021/ac202280f. Epub 2011 Nov 21. PMID: 22077671.
