OBBA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 111015

CAS#: 133800-88-1

Description: OBBA is a phospholipase A2 antagonist.


Chemical Structure

img
OBBA
CAS# 133800-88-1

Theoretical Analysis

MedKoo Cat#: 111015
Name: OBBA
CAS#: 133800-88-1
Chemical Formula: C28H44O3
Exact Mass: 428.33
Molecular Weight: 428.657
Elemental Analysis: C, 78.46; H, 10.35; O, 11.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: 3-(4-octadecylbenzoyl)acrylic acid; 3-Obaa; 3 Obaa; 3Obaa; 4-Oxo-4-(3-(1-propylpentadecyl)phenyl)-2-butenoic acid; OBBA; 3-(4-Octadecyl)benzoylacrylic acid

IUPAC/Chemical Name: (E)-4-(3-(octadecan-4-yl)phenyl)-4-oxobut-2-enoic acid

InChi Key: OLTDVZPGSDCOGR-QURGRASLSA-N

InChi Code: InChI=1S/C28H44O3/c1-3-5-6-7-8-9-10-11-12-13-14-15-18-24(17-4-2)25-19-16-20-26(23-25)27(29)21-22-28(30)31/h16,19-24H,3-15,17-18H2,1-2H3,(H,30,31)/b22-21+

SMILES Code: CCCCCCCCCCCCCCC(CCC)c1cccc(c1)C(=O)\C=C\C(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 428.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1. Kethineedi VR, Crivat G, Tarr MA, Rosenzweig Z. Quantum dot-NBD-liposome luminescent probes for monitoring phospholipase A2 activity. Anal Bioanal Chem. 2013 Dec;405(30):9729-37. doi: 10.1007/s00216-013-7422-z. Epub 2013 Oct 31. PMID: 24173659.

2. Sabirsh A, Bristulf J, Karlsson U, Owman C, Haeggström JZ. Non-specific effects of leukotriene synthesis inhibitors on HeLa cell physiology. Prostaglandins Leukot Essent Fatty Acids. 2005 Dec;73(6):431-40. doi: 10.1016/j.plefa.2005.08.004. Epub 2005 Sep 19. PMID: 16171988.


3. Nofer JR, Junker R, Walter M, Seedorf U, Assmann G, Zidek W, Tepel M. Phospholipase A(2) is involved in thapsigargin-induced sodium influx in human lymphocytes. Arch Biochem Biophys. 2000 Feb 15;374(2):213-21. doi: 10.1006/abbi.1999.1588. PMID: 10666300.

4. Abate A, Giessler J, Giessler C, Pönicke K, Hirschelmann R, Nuhn P. Inhibition of mediator release from anaphylactic guinea pig hearts by the novel phospholipase A2 inhibitor 3-(4-octadecylbenzoyl) acrylic acid. Inflamm Res. 1997 Aug;46 Suppl 2:S137-8. doi: 10.1007/s000110050143. PMID: 9297549.

5. Stanton PK. Phospholipase A2 activation is not required for long-term synaptic depression. Eur J Pharmacol. 1995 Feb 6;273(3):R7-9. doi: 10.1016/0014-2999(95)00022-d. PMID: 7737325.