WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464720
Description: A‑1293102 is a Potent and Selective BCL‑XL Inhibitor. A-1293102 exhibited picomolar binding affinity to BCL-XL and both efficiently and selectively killed BCL-XL-dependent tumor cells. A-1293102 represents one of the few distinct structural series of selective BCL-XL inhibitors, and thus serves as a useful tool for biological studies as well as a lead compound for further optimization.
MedKoo Cat#: 464720
Chemical Formula: C42H38F3N7O7S5
Exact Mass: 969.1388
Molecular Weight: 970.1032
Elemental Analysis: C, 52.00; H, 3.95; F, 5.88; N, 10.11; O, 11.54; S, 16.52
This product is not in stock, which may be available by custom synthesis.
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Synonym: A‑1293102; A 1293102; A1293102;
IUPAC/Chemical Name: (R)-2-(8-((benzo[d]thiazol-2-yl-l2-azanyl)carbonyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)-l2-azanyl)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)thiazole-4-carboxamide
InChi Key: ZYKSELSXHNKKDM-MUUNZHRXSA-N
InChi Code: InChI=1S/C42H38F3N7O7S5/c43-42(44,45)63(55,56)37-23-30(13-14-34(37)46-28(16-17-51-19-21-59-22-20-51)25-60-29-8-2-1-3-9-29)64(57,58)50-39(54)35-26-61-41(48-35)52-18-15-27-7-6-10-31(32(27)24-52)38(53)49-40-47-33-11-4-5-12-36(33)62-40/h1-14,23,26,28H,15-22,24-25H2,(H,50,54)/t28-/m1/s1
SMILES Code: O=C(C1=C(CN(C2=NC(C(NS(C3=CC=C([N][C@@H](CSC4=CC=CC=C4)CCN5CCOCC5)C(S(=O)(C(F)(F)F)=O)=C3)(=O)=O)=O)=CS2)CC6)C6=CC=C1)[N]C7=NC8=C(S7)C=CC=C8
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 970.1032 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|