5-Fluoro-thalidomide
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MedKoo CAT#: 408149

CAS#: 835616-61-0

Description: 5-Fluoro-thalidomide is a useful precursor for synthesis of PROTAC degrader. 5-Fluoro-thalidomide is a Thalidomide-based cereblon ligand that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.


Chemical Structure

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5-Fluoro-thalidomide
CAS# 835616-61-0

Theoretical Analysis

MedKoo Cat#: 408149
Name: 5-Fluoro-thalidomide
CAS#: 835616-61-0
Chemical Formula: C13H9FN2O4
Exact Mass: 276.0546
Molecular Weight: 276.2234
Elemental Analysis: C, 56.53; H, 3.28; F, 6.88; N, 10.14; O, 23.17

Price and Availability

Size Price Availability Quantity
200.0mg USD 350.0 2 Weeks
500.0mg USD 650.0 2 Weeks
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Synonym: Thalidomide 5-fluoride; 5-Fluoro-thalidomide;

IUPAC/Chemical Name: 2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione

InChi Key: MPQLCQKBYRSPNA-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H9FN2O4/c14-6-1-2-7-8(5-6)13(20)16(12(7)19)9-3-4-10(17)15-11(9)18/h1-2,5,9H,3-4H2,(H,15,17,18)

SMILES Code: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(F)=C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 276.2234 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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