WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 333957

CAS#: 91188-00-0

Description: Merafloxacin, also known as CI 934, is a fluoroquinolone antibacterial, which was also identified as a −1 PRF inhibitor of SARS-CoV-2. Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on −1 PRF of other beta coronaviruses. Importantly, frameshift inhibition by merafloxacin substantially impedes SARS-CoV-2 replication in Vero E6 cells, thereby providing the proof of principle of targeting −1 PRF as an effective antiviral strategy for SARS-CoV-2.

Chemical Structure

CAS# 91188-00-0

Theoretical Analysis

MedKoo Cat#: 333957
Name: Merafloxacin
CAS#: 91188-00-0
Chemical Formula: C19H23F2N3O
Exact Mass: 379.1707
Molecular Weight: 379.4078
Elemental Analysis: C, 60.15; H, 6.11; F, 10.01; N, 11.08; O, 12.65

Price and Availability

Size Price Availability Quantity
5.0mg USD 140.0 Ready to ship
10.0mg USD 250.0 Ready to ship
25.0mg USD 450.0 Ready to ship
50.0mg USD 750.0 Ready to ship
100.0mg USD 1250.0 Ready to ship
200.0mg USD 1950.0 Ready to ship
500.0mg USD 2950.0 Ready to ship
1.0g USD 3850.0 Ready to ship
2.0g USD 6850.0 Ready to ship
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Synonym: CI 934; CI-934; CI934; Merafloxacin;

IUPAC/Chemical Name: 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid


InChi Code: InChI=1S/C19H23F2N3O3/c1-3-22-8-11-5-6-24(9-11)17-14(20)7-12-16(15(17)21)23(4-2)10-13(18(12)25)19(26)27/h7,10-11,22H,3-6,8-9H2,1-2H3,(H,26,27)


Appearance: Solid powder

Purity: >97% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 379.4078 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Sun Y, Abriola L, Surovtseva YV, Lindenbach BD, Guo JU. Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro. bioRxiv [Preprint]. 2020 Oct 21:2020.10.21.349225. doi: 10.1101/2020.10.21.349225. PMID: 33106809; PMCID: PMC7587830.