IUN40061
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464703

CAS#: 101140-06-1

Description: IUN40061 is a polyketide synthase-derived biflavonoid that has been found in Hypericum and has diverse biological activities. It inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 4.5 µM) and stimulates glucose uptake in 3T3-L1 adipocyte cells when used at concentrations of 5 and 10 µM. IUN40061 inhibits the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, and CYP1A2 (Kis = 0.038, 0.32, and 0.95 µM, respectively). It reverses cell death induced by kainate and NMDA in isolated rat embryonic hippocampal neurons when used at a concentration of 10 µM. IUN40061 (8 mg/kg) decreases carrageenan-induced paw edema and protects against gastric lesions induced by indomethacin in rats. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).

Chemical Structure

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IUN40061
CAS# 101140-06-1
Instruction

Theoretical Analysis

MedKoo Cat#: 464703
Name: IUN40061
CAS#: 101140-06-1
Chemical Formula: C30H18O10
Exact Mass: 538.09
Molecular Weight: 538.464
Elemental Analysis: C, 66.92; H, 3.37; O, 29.71

Price and Availability

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1mg USD 265 2 Weeks
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Synonym: IUN40061; IUN 40061; IUN-40061; 3,8'-Biapigenin; I3,II8-Biapigenin;

IUPAC/Chemical Name: 5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-4H,4'H-[3,8'-bichromene]-4,4'-dione

InChi Key: IQAMTZLKUHMPPE-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H18O10/c31-15-5-1-13(2-6-15)22-12-21(37)24-19(35)11-20(36)26(30(24)39-22)27-28(38)25-18(34)9-17(33)10-23(25)40-29(27)14-3-7-16(32)8-4-14/h1-12,31-36H

SMILES Code: O=C1C=C(OC2=C1C(O)=CC(O)=C2C3=C(OC4=C(C3=O)C(O)=CC(O)=C4)C5=CC=C(C=C5)O)C6=CC=C(C=C6)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 538.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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5: Morse RK, Vergnes JP, Malloy J, McManus IR. Sites of biological methylation of proteins in cultured chick muscle cells. Biochemistry. 1975 Sep 23;14(19):4316-25. doi: 10.1021/bi00690a028. PMID: 1101948.