Diosgenin palmitate
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MedKoo CAT#: 555991

CAS#: 4952-66-3

Description: Diosgenin palmitate, also known as Diosgenin hexadecanoate, is the hexadecanoic ester of Diosgenin. Diosgenin, a phytosteroid sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam, such as the Kokoro. The sugar-free (aglycone) product of such hydrolysis, diosgenin is used for the commercial synthesis of cortisone, pregnenolone, progesterone, and other steroid products.


Chemical Structure

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Diosgenin palmitate
CAS# 4952-66-3

Theoretical Analysis

MedKoo Cat#: 555991
Name: Diosgenin palmitate
CAS#: 4952-66-3
Chemical Formula: C43H72O4
Exact Mass: 652.5431
Molecular Weight: 653.045
Elemental Analysis: C, 79.09; H, 11.11; O, 9.80

Price and Availability

Size Price Availability Quantity
50.0mg USD 950.0 2 Weeks
100.0mg USD 1650.0 2 Weeks
200.0mg USD 2650.0 2 Weeks
500.0mg USD 3650.0 2 Weeks
1.0g USD 4650.0 2 Weeks
2.0g USD 7650.0 2 Weeks
Bulk inquiry

Synonym: Diosgenin palmitate; Diosgenin hexadecanoate; Spirost-5-en-3β-ol, palmitate; Spirost-5-en-3-ol, hexadecanoate, (3β,25R)- (9CI);

IUPAC/Chemical Name: (4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl palmitate

InChi Key: UTLFPCHHNIPLBC-PUYSEAGNSA-N

InChi Code: InChI=1S/C43H72O4/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-39(44)46-34-23-25-41(4)33(28-34)20-21-35-36(41)24-26-42(5)37(35)29-38-40(42)32(3)43(47-38)27-22-31(2)30-45-43/h20,31-32,34-38,40H,6-19,21-30H2,1-5H3/t31-,32+,34+,35-,36+,37+,38+,40+,41+,42+,43-/m1/s1

SMILES Code: [H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](OC(CCCCCCCCCCCCCCC)=O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 653.045 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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This message contains search results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM). Do not reply directly to this message

Sent On: Tue May 11 15:14:43 2021

Search: Diosgenin Filters: Review

20 selected items

PubMed Results
Items 1-20 of 20 (Display the 20 citations in PubMed)

1: Wu FC, Jiang JG. Effects of diosgenin and its derivatives on atherosclerosis. Food Funct. 2019 Nov 1;10(11):7022-7036. doi: 10.1039/c9fo00749k. Epub 2019 Nov 5. PMID: 31687707.

2: Sethi G, Shanmugam MK, Warrier S, Merarchi M, Arfuso F, Kumar AP, Bishayee A. Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review. Nutrients. 2018 May 19;10(5):645. doi: 10.3390/nu10050645. PMID: 29783752; PMCID: PMC5986524.

3: Gan Q, Wang J, Hu J, Lou G, Xiong H, Peng C, Zheng S, Huang Q. The role of diosgenin in diabetes and diabetic complications. J Steroid Biochem Mol Biol. 2020 Apr;198:105575. doi: 10.1016/j.jsbmb.2019.105575. Epub 2019 Dec 30. PMID: 31899316.

4: Parama D, Boruah M, Yachna K, Rana V, Banik K, Harsha C, Thakur KK, Dutta U, Arya A, Mao X, Ahn KS, Kunnumakkara AB. Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases. Life Sci. 2020 Nov 1;260:118182. doi: 10.1016/j.lfs.2020.118182. Epub 2020 Aug 8. PMID: 32781063.

5: Cai B, Zhang Y, Wang Z, Xu D, Jia Y, Guan Y, Liao A, Liu G, Chun C, Li J. Therapeutic Potential of Diosgenin and Its Major Derivatives against Neurological Diseases: Recent Advances. Oxid Med Cell Longev. 2020 Mar 6;2020:3153082. doi: 10.1155/2020/3153082. PMID: 32215172; PMCID: PMC7079249.

6: Lian Y, Wen D, Meng X, Wang X, Li H, Hao L, Xue H, Zhao J. Inhibition of invadopodia formation by diosgenin in tumor cells. Oncol Lett. 2020 Dec;20(6):283. doi: 10.3892/ol.2020.12148. Epub 2020 Sep 23. PMID: 33014161; PMCID: PMC7520800.

7: Chen Y, Tang YM, Yu SL, Han YW, Kou JP, Liu BL, Yu BY. Advances in the pharmacological activities and mechanisms of diosgenin. Chin J Nat Med. 2015 Aug;13(8):578-87. doi: 10.1016/S1875-5364(15)30053-4. PMID: 26253490.

8: Jesus M, Martins AP, Gallardo E, Silvestre S. Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology. J Anal Methods Chem. 2016;2016:4156293. doi: 10.1155/2016/4156293. Epub 2016 Dec 28. PMID: 28116217; PMCID: PMC5225340.

9: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Fenugreek. 2021 Feb 15. PMID: 30000838.

10: Nazir R, Kumar V, Gupta S, Dwivedi P, Pandey DK, Dey A. Biotechnological strategies for the sustainable production of diosgenin from Dioscorea spp. Appl Microbiol Biotechnol. 2021 Jan;105(2):569-585. doi: 10.1007/s00253-020-11055-3. Epub 2021 Jan 6. PMID: 33404834.

11: Bergeron MF, Mountjoy M, Armstrong N, Chia M, Côté J, Emery CA, Faigenbaum A, Hall G Jr, Kriemler S, Léglise M, Malina RM, Pensgaard AM, Sanchez A, Soligard T, Sundgot-Borgen J, van Mechelen W, Weissensteiner JR, Engebretsen L. International Olympic Committee consensus statement on youth athletic development. Br J Sports Med. 2015 Jul;49(13):843-51. doi: 10.1136/bjsports-2015-094962. PMID: 26084524.

12: Sahu P, Gidwani B, Dhongade HJ. Pharmacological activities of dehydroepiandrosterone: A review. Steroids. 2020 Jan;153:108507. doi: 10.1016/j.steroids.2019.108507. Epub 2019 Oct 3. PMID: 31586606.

13: Fuller S, Stephens JM. Diosgenin, 4-hydroxyisoleucine, and fiber from fenugreek: mechanisms of actions and potential effects on metabolic syndrome. Adv Nutr. 2015 Mar 13;6(2):189-97. doi: 10.3945/an.114.007807. PMID: 25770257; PMCID: PMC4352177.

14: Raju J, Mehta R. Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin. Nutr Cancer. 2009;61(1):27-35. doi: 10.1080/01635580802357352. PMID: 19116873.

15: Bucci LR. Selected herbals and human exercise performance. Am J Clin Nutr. 2000 Aug;72(2 Suppl):624S-36S. doi: 10.1093/ajcn/72.2.624S. PMID: 10919969.

16: Li X, Liu S, Qu L, Chen Y, Yuan C, Qin A, Liang J, Huang Q, Jiang M, Zou W. Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases. J Ethnopharmacol. 2021 Jun 28;274:114018. doi: 10.1016/j.jep.2021.114018. Epub 2021 Mar 11. PMID: 33716083.

17: Abarikwu SO, Onuah CL, Singh SK. Plants in the management of male infertility. Andrologia. 2020 Apr;52(3):e13509. doi: 10.1111/and.13509. Epub 2020 Jan 28. PMID: 31989693.

18: Gong J, Fang K, Dong H, Wang D, Hu M, Lu F. Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis. J Ethnopharmacol. 2016 Dec 24;194:260-268. doi: 10.1016/j.jep.2016.08.003. Epub 2016 Aug 2. PMID: 27496582.

19: Xia N, Li H. The role of perivascular adipose tissue in obesity-induced vascular dysfunction. Br J Pharmacol. 2017 Oct;174(20):3425-3442. doi: 10.1111/bph.13650. Epub 2016 Nov 17. PMID: 27761903; PMCID: PMC5610151.

20: Santos HO, Howell S, Teixeira FJ. Beyond tribulus (Tribulus terrestris L.): The effects of phytotherapics on testosterone, sperm and prostate parameters. J Ethnopharmacol. 2019 May 10;235:392-405. doi: 10.1016/j.jep.2019.02.033. Epub 2019 Feb 18. PMID: 30790614.