WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555990

CAS#: 2367004-54-2

Description: XL092 is an ATP-competitive inhibitor of multiple RTKs including MET, VEGFR2, AXL and MER, with IC50 values in cell-based assays of 15, 1.6, 3.4, and 7.2 nM respectively. In xenograft studies, XL092 caused substantial tumor growth inhibition following 10 mg/kg daily oral dosing for 14 days. XL092 has good oral bioavailability and a significantly shorter half-life than cabozantinib.

Chemical Structure

CAS# 2367004-54-2

Theoretical Analysis

MedKoo Cat#: 555990
Name: XL092
CAS#: 2367004-54-2
Chemical Formula: C29H25FN4O5
Exact Mass: 528.1809
Molecular Weight: 528.5404
Elemental Analysis: C, 65.90; H, 4.77; F, 3.59; N, 10.60; O, 15.14

Price and Availability

Size Price Availability Quantity
5.0mg USD 150.0 Ready to ship
10.0mg USD 250.0 Ready to ship
25.0mg USD 450.0 Ready to ship
50.0mg USD 750.0 Ready to ship
100.0mg USD 1250.0 Ready to ship
200.0mg USD 2250.0 Ready to ship
500.0mg USD 3650.0 Ready to ship
1.0g USD 4850.0 Ready to ship
2.0g USD 7950.0 Ready to ship
Click to view more sizes and prices
Bulk inquiry

Synonym: JUN04542; JUN-04542; JUN 04542; XL092; XL-092; X L092; Zanzalintinib

IUPAC/Chemical Name: 1,1-Cyclopropanedicarboxamide, N-(4-fluorophenyl)-N'-[4-[[7-methoxy-6-[(methylamino)carbonyl]-4-quinolinyl]oxy]phenyl]-


InChi Code: InChI=1S/C29H25FN4O5/c1-31-26(35)22-15-21-23(16-25(22)38-2)32-14-11-24(21)39-20-9-7-19(8-10-20)34-28(37)29(12-13-29)27(36)33-18-5-3-17(30)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,35)(H,33,36)(H,34,37)

SMILES Code: O=C(C1(C(NC2=CC=C(OC3=CC=NC4=CC(OC)=C(C(NC)=O)C=C34)C=C2)=O)CC1)NC5=CC=C(F)C=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Biological target: XL092 is a potent inhibitor of the activity of Axl, Mer and C-Met kinase.
In vitro activity: TBD
In vivo activity: TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 528.5404 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.


5.0mg / USD 150.0

Additional Information

XL092 retains the target inhibition profile of the clinically active drug cabozantinib, simultaneously targeting MET, VEGFR2, AXL and MER. In preclinical studies XL092 showed potent pharmacodynamic inhibition of MET and VEGFR2 phosphorylation, which was associated with significant anti-tumor activity. PK data from the Phase 1 trial of XL092 shows a significantly shorter terminal half-life compared to cabozantinib, consistent with the desired profile.