C0818

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464663

CAS#: unknown

Description: C0818 is a novel inducer of ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 function.


Chemical Structure

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C0818
CAS# unknown

Theoretical Analysis

MedKoo Cat#: 464663
Name: C0818
CAS#: unknown
Chemical Formula: C21H22ClNO5
Exact Mass: 403.1187
Molecular Weight: 403.859
Elemental Analysis: C, 62.46; H, 5.49; Cl, 8.78; N, 3.47; O, 19.81

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: C0818; C 0818; C-0818;

IUPAC/Chemical Name: 3,5-bis((E)-4-hydroxy-3-methoxybenzylidene)piperidin-4-one hydrochloride

InChi Key: NRULDJYGPFISDL-OBQHEISASA-N

InChi Code: InChI=1S/C21H21NO5.ClH/c1-26-19-9-13(3-5-17(19)23)7-15-11-22-12-16(21(15)25)8-14-4-6-18(24)20(10-14)27-2;/h3-10,22-24H,11-12H2,1-2H3;1H/b15-7+,16-8+;

SMILES Code: O=C1/C(CNC/C1=C\C2=CC=C(O)C(OC)=C2)=C/C3=CC=C(O)C(OC)=C3.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 403.859 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Abdelmoaty AAA, Zhang P, Lin W, Fan YJ, Ye SN, Xu JH. C0818, a novel curcumin derivative, induces ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 function. Acta Pharmacol Sin. 2021 Apr 6. doi: 10.1038/s41401-021-00642-3. Epub ahead of print. PMID: 33824458.

2: Fan Y, Liu Y, Zhang L, Cai F, Zhu L, Xu J. C0818, a novel curcumin derivative, interacts with Hsp90 and inhibits Hsp90 ATPase activity. Acta Pharm Sin B. 2017 Jan;7(1):91-96. doi: 10.1016/j.apsb.2016.05.014. Epub 2016 Jun 18. PMID: 28119813; PMCID: PMC5237709.