D-544

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464653

CAS#: unknown

Description: D-544 is a novel potent triple reuptake inhibitor (DAT: Ki=29.6 nM; NET: Ki=2.14 nM; SERT: Ki=1.72 nM).


Chemical Structure

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D-544
CAS# unknown

Theoretical Analysis

MedKoo Cat#: 464653
Name: D-544
CAS#: unknown
Chemical Formula: C27H28N2O2
Exact Mass: 412.2151
Molecular Weight: 412.533
Elemental Analysis: C, 78.61; H, 6.84; N, 6.79; O, 7.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: D-544; D544; D 544;

IUPAC/Chemical Name: (2S,4R,5R)-5-(((1H-indol-6-yl)methyl)amino)-2-benzhydryltetrahydro-2H-pyran-4-ol

InChi Key: VRRFTGAVCZEFMN-CYXNTTPDSA-N

InChi Code: InChI=1S/C27H28N2O2/c30-25-16-26(27(21-7-3-1-4-8-21)22-9-5-2-6-10-22)31-18-24(25)29-17-19-11-12-20-13-14-28-23(20)15-19/h1-15,24-30H,16-18H2/t24-,25-,26+/m1/s1

SMILES Code: O[C@H](C1)[C@@H](CO[C@@H]1C(C2=CC=CC=C2)C3=CC=CC=C3)NCC4=CC5=C(C=CN5)C=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 412.533 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Santra S, Kortagere S, Vedachalam S, Gogoi S, Antonio T, Reith MEA, Dutta AK. Novel Potent Dopamine-Norepinephrine and Triple Reuptake Uptake Inhibitors Based on Asymmetric Pyran Template and Their Molecular Interactions with Monoamine Transporters. ACS Chem Neurosci. 2021 Apr 21;12(8):1406-1418. doi: 10.1021/acschemneuro.1c00078. Epub 2021 Apr 12. PMID: 33844493.