WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464653
Description: D-544 is a novel potent triple reuptake inhibitor (DAT: Ki=29.6 nM; NET: Ki=2.14 nM; SERT: Ki=1.72 nM).
MedKoo Cat#: 464653
Chemical Formula: C27H28N2O2
Exact Mass: 412.2151
Molecular Weight: 412.533
Elemental Analysis: C, 78.61; H, 6.84; N, 6.79; O, 7.76
This product is not in stock, which may be available by custom synthesis.
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Synonym: D-544; D544; D 544;
IUPAC/Chemical Name: (2S,4R,5R)-5-(((1H-indol-6-yl)methyl)amino)-2-benzhydryltetrahydro-2H-pyran-4-ol
InChi Key: VRRFTGAVCZEFMN-CYXNTTPDSA-N
InChi Code: InChI=1S/C27H28N2O2/c30-25-16-26(27(21-7-3-1-4-8-21)22-9-5-2-6-10-22)31-18-24(25)29-17-19-11-12-20-13-14-28-23(20)15-19/h1-15,24-30H,16-18H2/t24-,25-,26+/m1/s1
SMILES Code: O[C@H](C1)[C@@H](CO[C@@H]1C(C2=CC=CC=C2)C3=CC=CC=C3)NCC4=CC5=C(C=CN5)C=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 412.533 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Santra S, Kortagere S, Vedachalam S, Gogoi S, Antonio T, Reith MEA, Dutta AK. Novel Potent Dopamine-Norepinephrine and Triple Reuptake Uptake Inhibitors Based on Asymmetric Pyran Template and Their Molecular Interactions with Monoamine Transporters. ACS Chem Neurosci. 2021 Apr 21;12(8):1406-1418. doi: 10.1021/acschemneuro.1c00078. Epub 2021 Apr 12. PMID: 33844493.