WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464651
Description: D-473 is a novel orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters.
MedKoo Cat#: 464651
Chemical Formula: C26H27F2NO3
Exact Mass: 439.1959
Molecular Weight: 439.5028
Elemental Analysis: C, 71.05; H, 6.19; F, 8.65; N, 3.19; O, 10.92
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Synonym: D-473; D473; D 473;
IUPAC/Chemical Name: (2S,4R,5R)-2-(bis(4-fluorophenyl)methyl)-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol
InChi Key: BEJMRCNDXXJWEL-SDHSZQHLSA-N
InChi Code: InChI=1S/C26H27F2NO3/c1-31-22-12-2-17(3-13-22)15-29-23-16-32-25(14-24(23)30)26(18-4-8-20(27)9-5-18)19-6-10-21(28)11-7-19/h2-13,23-26,29-30H,14-16H2,1H3/t23-,24-,25+/m1/s1
SMILES Code: O[C@@H]1C[C@@H](C(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)OC[C@H]1NCC4=CC=C(OC)C=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 439.5028 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Dutta AK, Santra S, Sharma H, Voshavar C, Xu L, Mabrouk O, Antonio T, Reith ME. Pharmacological and behavioral characterization of D-473, an orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters. PLoS One. 2014 Nov 26;9(11):e113420. doi: 10.1371/journal.pone.0113420. PMID: 25427177; PMCID: PMC4245125.
2: Santra S, Kortagere S, Vedachalam S, Gogoi S, Antonio T, Reith MEA, Dutta AK. Novel Potent Dopamine-Norepinephrine and Triple Reuptake Uptake Inhibitors Based on Asymmetric Pyran Template and Their Molecular Interactions with Monoamine Transporters. ACS Chem Neurosci. 2021 Apr 21;12(8):1406-1418. doi: 10.1021/acschemneuro.1c00078. Epub 2021 Apr 12. PMID: 33844493.