WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464616

CAS#: unknown

Description: V-10367 is a non-immunosuppressive immunophilins ligand, demonstrating enhanced neuroregeneration in the peripheral nervous system and CNS.

Chemical Structure

CAS# unknown

Theoretical Analysis

MedKoo Cat#: 464616
Name: V-10367
CAS#: unknown
Chemical Formula: C35H42N2O7
Exact Mass: 602.30
Molecular Weight: 602.728
Elemental Analysis: C, 69.75; H, 7.02; N, 4.65; O, 18.58

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: V-10367; V10367; V 10367; V-10,367; V10,367; V 10,367;

IUPAC/Chemical Name: 1-phenyl-7-(pyridin-3-yl)heptan-4-yl (2S)-1-(2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxylate


InChi Code: InChI=1S/C35H42N2O7/c1-41-30-22-27(23-31(42-2)33(30)43-3)32(38)34(39)37-21-8-7-19-29(37)35(40)44-28(17-9-14-25-12-5-4-6-13-25)18-10-15-26-16-11-20-36-24-26/h4-6,11-13,16,20,22-24,28-29H,7-10,14-15,17-19,21H2,1-3H3/t28?,29-/m0/s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 602.728000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Toll EC, Seifalian AM, Birchall MA. The role of immunophilin ligands in nerve regeneration. Regen Med. 2011 Sep;6(5):635-52. doi: 10.2217/rme.11.43. PMID: 21916598. 2: Johnston TH, Brotchie JM. Drugs in development for Parkinson's disease. Curr Opin Investig Drugs. 2004 Jul;5(7):720-6. PMID: 15298067. 3: Rosenstiel P, Schramm P, Isenmann S, Brecht S, Eickmeier C, Bürger E, Herdegen T, Sievers J, Lucius R. Differential effects of immunophilin-ligands (FK506 and V-10,367) on survival and regeneration of rat retinal ganglion cells in vitro and after optic nerve crush in vivo. J Neurotrauma. 2003 Mar;20(3):297-307. doi: 10.1089/089771503321532888. PMID: 12820684. 4: Klettner A, Herdegen T. The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response. Br J Pharmacol. 2003 Mar;138(5):1004-12. doi: 10.1038/sj.bjp.0705132. PMID: 12642403; PMCID: PMC1573741. 5: Kupina NC, Detloff MR, Dutta S, Hall ED. Neuroimmunophilin ligand V-10,367 is neuroprotective after 24-hour delayed administration in a mouse model of diffuse traumatic brain injury. J Cereb Blood Flow Metab. 2002 Oct;22(10):1212-21. doi: 10.1097/01.wbc.0000037994.34930.bc. PMID: 12368660. 6: Klettner A, Baumgrass R, Zhang Y, Fischer G, Bürger E, Herdegen T, Mielke K. The neuroprotective actions of FK506 binding protein ligands: neuronal survival is triggered by de novo RNA synthesis, but is independent of inhibition of JNK and calcineurin. Brain Res Mol Brain Res. 2001 Dec 16;97(1):21-31. doi: 10.1016/s0169-328x(01)00286-8. PMID: 11744159. 7: Shefner JM, Brown RH Jr, Cole D, Chaturvedi P, Schoenfeld D, Pastuszak K, Matthews R, Upton-Rice M, Cudkowicz ME. Effect of neurophilin ligands on motor units in mice with SOD1 ALS mutations. Neurology. 2001 Nov 27;57(10):1857-61. doi: 10.1212/wnl.57.10.1857. PMID: 11723276.