WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464586
CAS#: 2266569-73-5
Description: UMB298 is a Potent and Selective CBP/P300 Inhibitor with CBP IC50= 72 nM.
MedKoo Cat#: 464586
Name: UMB298
CAS#: 2266569-73-5
Chemical Formula: C27H31ClN4O2
Exact Mass: 478.2136
Molecular Weight: 479.021
Elemental Analysis: C, 67.70; H, 6.52; Cl, 7.40; N, 11.70; O, 6.68
Synonym: UMB298; UMB-298; UMB 298;
IUPAC/Chemical Name: 2-(3-chloro-4-methoxyphenethyl)-N-cyclohexyl-7-(3,5-dimethylisoxazol-4-yl)imidazo[1,2-a]pyridin-3-amine
InChi Key: NZXSWCLCRDCHGN-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H31ClN4O2/c1-17-26(18(2)34-31-17)20-13-14-32-25(16-20)30-23(27(32)29-21-7-5-4-6-8-21)11-9-19-10-12-24(33-3)22(28)15-19/h10,12-16,21,29H,4-9,11H2,1-3H3
SMILES Code: ClC1=CC(CCC2=C(NC3CCCCC3)N4C(C=C(C5=C(C)ON=C5C)C=C4)=N2)=CC=C1OC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 479.021 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Muthengi A, Wimalasena VK, Yosief HO, Bikowitz MJ, Sigua LH, Wang T, Li D, Gaieb Z, Dhawan G, Liu S, Erickson J, Amaro RE, Schönbrunn E, Qi J, Zhang W. Development of Dimethylisoxazole-Attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors. J Med Chem. 2021 Apr 19. doi: 10.1021/acs.jmedchem.0c02232. Epub ahead of print. PMID: 33872011.
