VT-107
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MedKoo CAT#: 408144

CAS#: 2417718-63-7 (S-isomer)

Description: VT-107 is a potent and selective TEAD Auto-palmitoylation inhibitor that Inhibits Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT107 is an analogous to VT104. VT107 prevented palmitoylation of the TEAD1 protein. VT107 decreased the levels of palmitoylated TEAD3 and TEAD4 and increased the levels of unpalmitoylated TEAD3 and TEAD4.

Chemical Structure

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VT-107
CAS# 2417718-63-7 (S-isomer)
Instruction

Theoretical Analysis

MedKoo Cat#: 408144
Name: VT-107
CAS#: 2417718-63-7 (S-isomer)
Chemical Formula: C25H20F3N3O
Exact Mass: 435.16
Molecular Weight: 435.450
Elemental Analysis: C, 68.96; H, 4.63; F, 13.09; N, 9.65; O, 3.67

Price and Availability

Size Price Availability Quantity
5mg USD 750 2 Weeks
10mg USD 1350 2 Weeks
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Related CAS #: 2417718-63-7 (S-isomer)   2417718-64-8 (R-isomer)   2417720-81-9 (Racemate)    

Synonym: VT-107; VT 107; VT107;

IUPAC/Chemical Name: (S)-N-(1-(6-aminopyridin-2-yl)ethyl)-5-(4-(trifluoromethyl)phenyl)-2-naphthamide

InChi Key: OBEXKSHQMHIUFP-HNNXBMFYSA-N

InChi Code: InChI=1S/C25H20F3N3O/c1-15(22-6-3-7-23(29)31-22)30-24(32)18-10-13-21-17(14-18)4-2-5-20(21)16-8-11-19(12-9-16)25(26,27)28/h2-15H,1H3,(H2,29,31)(H,30,32)/t15-/m0/s1

SMILES Code: C[C@@H](C1=NC(N)=CC=C1)NC(C2=CC=C3C(C=CC=C3C4=CC=C(C(F)(F)F)C=C4)=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 435.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Tang TT, Konradi AW, Feng Y, Peng X, Ma M, Li J, Yu FX, Guan KL, Post L. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Apr 13:molcanther.0717.2020. doi: 10.1158/1535-7163.MCT-20-0717. Epub ahead of print. PMID: 33850002.