Edetate disodium
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MedKoo CAT#: 413833

CAS#: 6381-92-6

Description: Edetate disodium is a chelating agent ( CHELATING AGENTS) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive


Chemical Structure

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Edetate disodium
CAS# 6381-92-6

Theoretical Analysis

MedKoo Cat#: 413833
Name: Edetate disodium
CAS#: 6381-92-6
Chemical Formula: C10H18N2Na2O10
Exact Mass: 372.08
Molecular Weight: 372.240
Elemental Analysis: C, 32.27; H, 4.87; N, 7.53; Na, 12.35; O, 42.98

Price and Availability

Size Price Availability Quantity
5g USD 250 2 Weeks
25g USD 450 2 Weeks
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Synonym: Edetate disodium; Disodium edetate; Endrate; Disodium EDTA dihydrate

IUPAC/Chemical Name: Acetic acid, (ethylenedinitrilo)tetra-, disodium salt, dihydrate

InChi Key: OVBJJZOQPCKUOR-UHFFFAOYSA-L

InChi Code: InChI=1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2

SMILES Code: O=C([O-])CN(CC([O-])=O)CCN(CC(O)=O)CC(O)=O.[H]O[H].[H]O[H].[Na+].[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 372.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Alam ZH, Ujueta F, Arenas IA, Nigra AE, Navas-Acien A, Lamas GA. Urinary Metal Levels after Repeated Edetate Disodium Infusions: Preliminary Findings. Int J Environ Res Public Health. 2020 Jun 29;17(13):4684. doi: 10.3390/ijerph17134684. PMID: 32610666; PMCID: PMC7370001.

2: Lamas GA, Issa OM. Edetate Disodium-Based Treatment for Secondary Prevention in Post-Myocardial Infarction Patients. Curr Cardiol Rep. 2016 Feb;18(2):20. doi: 10.1007/s11886-015-0690-9. PMID: 26797807.

3: Yarbrough M, Hodge T, Menard D, Jerome R, Ryczek J, Moore D, Baldus P, Warne N, Ohtake S. Edetate Disodium as a Polysorbate Degradation and Monoclonal Antibody Oxidation Stabilizer. J Pharm Sci. 2019 Apr;108(4):1631-1635. doi: 10.1016/j.xphs.2018.11.031. Epub 2018 Nov 29. PMID: 30502482.

4: Bradberry S, Vale A. A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning. Clin Toxicol (Phila). 2009 Nov;47(9):841-58. doi: 10.3109/15563650903321064. PMID: 19852620.

5: Sultan S, Murarka S, Jahangir A, Mookadam F, Tajik AJ, Jahangir A. Chelation therapy in cardiovascular disease: an update. Expert Rev Clin Pharmacol. 2017 Aug;10(8):843-854. doi: 10.1080/17512433.2017.1339601. Epub 2017 Jun 19. PMID: 28597699.

6: Sakthithasan K, Lévy P, Poupon J, Garnier R. A comparative study of edetate calcium disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults. Clin Toxicol (Phila). 2018 Nov;56(11):1143-1149. doi: 10.1080/15563650.2018.1478424. Epub 2018 Jun 11. PMID: 29889577.

7: Fukada T, Ozaki M. Microbial growth in propofol formulations with disodium edetate and the influence of venous access system dead space. Anaesthesia. 2007 Jun;62(6):575-80. doi: 10.1111/j.1365-2044.2007.05002.x. PMID: 17506735.

8: Arenas IA, Navas-Acien A, Ergui I, Lamas GA. Enhanced vasculotoxic metal excretion in post-myocardial infarction patients following a single edetate disodium-based infusion. Environ Res. 2017 Oct;158:443-449. doi: 10.1016/j.envres.2017.06.039. Epub 2017 Jul 6. PMID: 28689036.

9: Kumar N, Soni S, Jaimini A, Ahmad FJ, Bhatnagar A, Mittal G. Edetate calcium disodium nanoparticle dry powder inhalation: a novel approach against heavy metal decorporation. Int J Pharm. 2011 Sep 15;416(1):376-83. doi: 10.1016/j.ijpharm.2011.06.038. Epub 2011 Jun 28. PMID: 21740960.

10: Chisolm JJ Jr. Mobilization of lead by calcium disodium edetate. A reappraisal. Am J Dis Child. 1987 Dec;141(12):1256-7. doi: 10.1001/archpedi.1987.04460120018020. PMID: 3120574.