WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576541
CAS#: 129689-30-1 (free base)
Description: ZD7114, also known as ICI-D7114, is a selective adrenoceptor agonist of brown fat and thermogenesis. ICI D7114 stimulates thermogenesis at doses that have little effect on beta 1 or beta 2 adrenoceptors. Treatment with ICI D7114 activates BAT and thermogenesis even in species and situations where the intrinsic capacity is low. ICI D7114 has beneficial effects in animal models of obesity and disturbed glucose and lipid homeostasis.
MedKoo Cat#: 576541
Name: ZD7114 free base
CAS#: 129689-30-1 (free base)
Chemical Formula: C22H30N2O6
Exact Mass: 418.2104
Molecular Weight: 418.49
Elemental Analysis: C, 63.14; H, 7.23; N, 6.69; O, 22.94
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Synonym: ICI D7114; ICID7114; ICI-D7114; ZD 7114; ZD7114; ZD-7114
IUPAC/Chemical Name: Acetamide, 2-(4-(2-((2-hydroxy-3-phenoxypropyl)amino)ethoxy)phenoxy)-N-(2-methoxyethyl)-, (S)-
InChi Key: RVMBDLSFFNKKLG-SFHVURJKSA-N
InChi Code: InChI=1S/C22H30N2O6/c1-27-13-12-24-22(26)17-30-21-9-7-20(8-10-21)28-14-11-23-15-18(25)16-29-19-5-3-2-4-6-19/h2-10,18,23,25H,11-17H2,1H3,(H,24,26)/t18-/m0/s1
SMILES Code: COCCNC(=O)COc1ccc(OCCNC[C@H](O)COc2ccccc2)cc1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 418.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Holloway BR, Howe R, Rao BS, Stribling D. ICI D7114: a novel selective adrenoceptor agonist of brown fat and thermogenesis. Am J Clin Nutr. 1992 Jan;55(1 Suppl):262S-264S. doi: 10.1093/ajcn/55.1.262s. PMID: 1345891.
2. Holloway BR, Howe R, Rao BS, Stribling D, Mayers RM, Briscoe MG, Jackson JM. ICI D7114 a novel selective beta-adrenoceptor agonist selectively stimulates brown fat and increases whole-body oxygen consumption. Br J Pharmacol. 1991 Sep;104(1):97-104. doi: 10.1111/j.1476-5381.1991.tb12391.x. PMID: 1686210; PMCID: PMC1908265.