ICI-206970

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576528

CAS#: 119646-52-5

Description: ICI-206970 is a eukalemic diuretic with effects on sodium and water excretion similar to hydrochlorothiazide.


Chemical Structure

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ICI-206970
CAS# 119646-52-5

Theoretical Analysis

MedKoo Cat#: 576528
Name: ICI-206970
CAS#: 119646-52-5
Chemical Formula: C21H31BrClN7O2
Exact Mass: 527.1411
Molecular Weight: 528.88
Elemental Analysis: C, 47.69; H, 5.91; Br, 15.11; Cl, 6.70; N, 18.54; O, 6.05

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ICI206970; ICI 206970; ICI-206970

IUPAC/Chemical Name: Pyrazinecarboxamide, 3,5-diamino-N-(2-((2-(((3-bromo-5-(1,1-dimethylethyl)-2-hydroxyphenyl)methyl)amino)ethyl)methylamino)ethyl)-6-chloro-

InChi Key: BOOGSGUHOOWQBH-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H31BrClN7O2/c1-21(2,3)13-9-12(16(31)14(22)10-13)11-26-5-7-30(4)8-6-27-20(32)15-18(24)29-19(25)17(23)28-15/h9-10,26,31H,5-8,11H2,1-4H3,(H,27,32)(H4,24,25,29)

SMILES Code: CN(CCNCc1cc(cc(Br)c1O)C(C)(C)C)CCNC(=O)c2nc(Cl)c(N)nc2N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 528.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Johnston PA, Kau ST. A micropuncture study on the renal site of action of ICI 206,970, a unique eukalemic diuretic. J Pharmacol Exp Ther. 1993 Feb;264(2):604-8. PMID: 8437111.

2. Kau S, Johnston P, Li J, Zuzack J, Leszczynska K, Yochim C, Schwartz J, Giles R. ICI 206,970: a novel eukalemic diuretic with calcium channel blocking activity. Methods Find Exp Clin Pharmacol. 1993 Jul-Aug;15(6):357-69. PMID: 8231455.

3. Howe BB, Keith RA, Do ML, Halterman TJ, Donahue JY, Schwartz JA, Kau ST. ICI 206,970: a novel calcium channel blocker with eukalemic diuretic activity. Pharmacology. 1993 Dec;47(6):369-77. doi: 10.1159/000139120. PMID: 8278459.