WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576528
Description: ICI-206970 is a eukalemic diuretic with effects on sodium and water excretion similar to hydrochlorothiazide.
MedKoo Cat#: 576528
Chemical Formula: C21H31BrClN7O2
Exact Mass: 527.1411
Molecular Weight: 528.88
Elemental Analysis: C, 47.69; H, 5.91; Br, 15.11; Cl, 6.70; N, 18.54; O, 6.05
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: ICI206970; ICI 206970; ICI-206970
IUPAC/Chemical Name: Pyrazinecarboxamide, 3,5-diamino-N-(2-((2-(((3-bromo-5-(1,1-dimethylethyl)-2-hydroxyphenyl)methyl)amino)ethyl)methylamino)ethyl)-6-chloro-
InChi Key: BOOGSGUHOOWQBH-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H31BrClN7O2/c1-21(2,3)13-9-12(16(31)14(22)10-13)11-26-5-7-30(4)8-6-27-20(32)15-18(24)29-19(25)17(23)28-15/h9-10,26,31H,5-8,11H2,1-4H3,(H,27,32)(H4,24,25,29)
SMILES Code: CN(CCNCc1cc(cc(Br)c1O)C(C)(C)C)CCNC(=O)c2nc(Cl)c(N)nc2N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 528.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Johnston PA, Kau ST. A micropuncture study on the renal site of action of ICI 206,970, a unique eukalemic diuretic. J Pharmacol Exp Ther. 1993 Feb;264(2):604-8. PMID: 8437111.
2. Kau S, Johnston P, Li J, Zuzack J, Leszczynska K, Yochim C, Schwartz J, Giles R. ICI 206,970: a novel eukalemic diuretic with calcium channel blocking activity. Methods Find Exp Clin Pharmacol. 1993 Jul-Aug;15(6):357-69. PMID: 8231455.
3. Howe BB, Keith RA, Do ML, Halterman TJ, Donahue JY, Schwartz JA, Kau ST. ICI 206,970: a novel calcium channel blocker with eukalemic diuretic activity. Pharmacology. 1993 Dec;47(6):369-77. doi: 10.1159/000139120. PMID: 8278459.