ICI-153110

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576516

CAS#: 87164-90-7

Description: ICI-153110 is a cyclic nucleotide phosphodiesterase inhibitor.


Chemical Structure

img
ICI-153110
CAS# 87164-90-7

Theoretical Analysis

MedKoo Cat#: 576516
Name: ICI-153110
CAS#: 87164-90-7
Chemical Formula: C11H11N3O
Exact Mass: 201.0902
Molecular Weight: 201.23
Elemental Analysis: C, 65.66; H, 5.51; N, 20.88; O, 7.95

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ICI 153110; ICI153110; ICI-153110

IUPAC/Chemical Name: 3(2H)-Pyridazinone, 4,5-dihydro-6-(2-(4-pyridinyl)ethenyl)-, (E)-

InChi Key: NTIZSASEORJCSP-OWOJBTEDSA-N

InChi Code: InChI=1S/C11H11N3O/c15-11-4-3-10(13-14-11)2-1-9-5-7-12-8-6-9/h1-2,5-8H,3-4H2,(H,14,15)/b2-1+

SMILES Code: O=C1CCC(=NN1)\C=C\c2ccncc2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 201.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1. Murray KJ, England PJ. Inhibitors of cyclic nucleotide phosphodiesterases as therapeutic agents. Biochem Soc Trans. 1992 May;20(2):460-4. doi: 10.1042/bst0200460. PMID: 1327922.

2. McKillop D, Pickup KJ. Different inhibition and induction profiles of hepatic drug metabolism in rats and dogs by two structurally related pyridyl diazinone cardiotonic agents. Biochem Pharmacol. 1991 Feb 1;41(3):411-7. doi: 10.1016/0006-2952(91)90538-g. PMID: 1994899.

3. Westwood FR, Iswaran TJ, Greaves P. Long-term effects of an inotropic phosphodiesterase inhibitor (ICI 153,110) on the rat salivary gland, harderian gland, and intestinal mucosa. Toxicol Pathol. 1991;19(3):214-23. doi: 10.1177/019262339101900303. PMID: 1780638.

4. Westwood FR, Iswaran TJ, Greaves P. Pathologic changes in blood vessels following administration of an inotropic vasodilator (ICI 153,110) to the rat. Fundam Appl Toxicol. 1990 May;14(4):797-809. doi: 10.1016/0272-0590(90)90304-3. PMID: 2361578.

5. Jafri SM, Reddy BR, Budzinski D, Goldberg AD, Pilla A, Levine TB. Acute neurohormonal and hemodynamic response to a new peak III phosphodiesterase inhibitor (ICI 153,110) in patients with chronic heart failure. J Cardiovasc Pharmacol. 1990 Sep;16(3):360-6. doi: 10.1097/00005344-199009000-00003. PMID: 1700205.