ICI-162846

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576515

CAS#: 84545-30-2

Description: ICI-162846 is a H2-antagonist that has been shown to inhibit both basal and pentagastrin stimulated acid secretion by 50% or more in a chronic duodenal ulcer model.

Chemical Structure

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ICI-162846
CAS# 84545-30-2
Instruction

Theoretical Analysis

MedKoo Cat#: 576515
Name: ICI-162846
CAS#: 84545-30-2
Chemical Formula: C11H17F3N6O
Exact Mass: 306.14
Molecular Weight: 306.290
Elemental Analysis: C, 43.14; H, 5.59; F, 18.61; N, 27.44; O, 5.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ICI 162846; ICI162846; ICI-162846

IUPAC/Chemical Name: 1H-Pyrazole-1-pentanamide, 3-((imino((2,2,2-trifluoroethyl)amino)methyl)amino)-

InChi Key: ALCSGJCIESECFD-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H17F3N6O/c12-11(13,14)7-17-10(16)18-9-4-6-20(19-9)5-2-1-3-8(15)21/h4,6H,1-3,5,7H2,(H2,15,21)(H3,16,17,18,19)

SMILES Code: NC(=O)CCCCn1ccc(NC(=N)NCC(F)(F)F)n1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 306.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Gompertz RH, Man WK, Li SK, Spencer J, Baron JH, Michalowski AS. Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model. Agents Actions. 1991 May;33(1-2):161-3. doi: 10.1007/BF01993155. PMID: 1716826.

2. Streett CS, Robertson JL, Crissman JW. Morphologic stomach findings in rats and mice treated with the H2 receptor antagonists, ICI 125,211 and ICI 162,846. Toxicol Pathol. 1988;16(2):299-304. doi: 10.1177/019262338801600223. PMID: 2903545.

3. Wilson JA, Johnston DA, Penston J, Wormsley KG. Inhibition of human gastric secretion by ICI 162,846--a new histamine H2-receptor antagonist. Br J Clin Pharmacol. 1986 Jun;21(6):685-9. doi: 10.1111/j.1365-2125.1986.tb05234.x. PMID: 2874823; PMCID: PMC1400977.