WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576515
Description: ICI-162846 is a H2-antagonist that has been shown to inhibit both basal and pentagastrin stimulated acid secretion by 50% or more in a chronic duodenal ulcer model.
MedKoo Cat#: 576515
Chemical Formula: C11H17F3N6O
Exact Mass: 306.1416
Molecular Weight: 306.29
Elemental Analysis: C, 43.14; H, 5.59; F, 18.61; N, 27.44; O, 5.22
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: ICI 162846; ICI162846; ICI-162846
IUPAC/Chemical Name: 1H-Pyrazole-1-pentanamide, 3-((imino((2,2,2-trifluoroethyl)amino)methyl)amino)-
InChi Key: ALCSGJCIESECFD-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H17F3N6O/c12-11(13,14)7-17-10(16)18-9-4-6-20(19-9)5-2-1-3-8(15)21/h4,6H,1-3,5,7H2,(H2,15,21)(H3,16,17,18,19)
SMILES Code: NC(=O)CCCCn1ccc(NC(=N)NCC(F)(F)F)n1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 306.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Gompertz RH, Man WK, Li SK, Spencer J, Baron JH, Michalowski AS. Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model. Agents Actions. 1991 May;33(1-2):161-3. doi: 10.1007/BF01993155. PMID: 1716826.
2. Streett CS, Robertson JL, Crissman JW. Morphologic stomach findings in rats and mice treated with the H2 receptor antagonists, ICI 125,211 and ICI 162,846. Toxicol Pathol. 1988;16(2):299-304. doi: 10.1177/019262338801600223. PMID: 2903545.
3. Wilson JA, Johnston DA, Penston J, Wormsley KG. Inhibition of human gastric secretion by ICI 162,846--a new histamine H2-receptor antagonist. Br J Clin Pharmacol. 1986 Jun;21(6):685-9. doi: 10.1111/j.1365-2125.1986.tb05234.x. PMID: 2874823; PMCID: PMC1400977.