WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576513
Description: ICI-153066 is a triazole antifungal antibiotic.
MedKoo Cat#: 576513
Chemical Formula: C16H12Cl2FN3O
Exact Mass: 351.0341
Molecular Weight: 352.19
Elemental Analysis: C, 54.57; H, 3.43; Cl, 20.13; F, 5.39; N, 11.93; O, 4.54
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: ICI-153066; ICI 153066; ICI153066
IUPAC/Chemical Name: 1H-1,2,4-Triazole-1-ethanol, alpha-(2,4-dichlorophenyl)-alpha-(4-fluorophenyl)-
InChi Key: RBNYRMJSBJAEIA-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H12Cl2FN3O/c17-12-3-6-14(15(18)7-12)16(23,8-22-10-20-9-21-22)11-1-4-13(19)5-2-11/h1-7,9-10,23H,8H2
SMILES Code: OC(Cn1cncn1)(c2ccc(F)cc2)c3ccc(Cl)cc3Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 352.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Hitchcock CA, Barrett-Bee KJ, Russell NJ. The lipid composition and permeability to the triazole antifungal antibiotic ICI 153066 of serum-grown mycelial cultures of Candida albicans. J Gen Microbiol. 1989 Jul;135(7):1949-55. doi: 10.1099/00221287-135-7-1949. PMID: 2693607.
2. Hitchcock CA, Dickinson K, Brown SB, Evans EG, Adams DJ. Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14 alpha-sterol demethylase purified from Candida albicans. Biochem J. 1990 Mar 1;266(2):475-80. doi: 10.1042/bj2660475. PMID: 2180400; PMCID: PMC1131156.