Tracazolate HCl

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MedKoo CAT#: 576510

CAS#: 1135210-68-2 (HCl)

Description: Tracazolate is an allosteric modulator of GABAA receptors. Tracazolate interacts with gamma-aminobutyric acid (GABA)(A) receptors, adenosine receptors, and phosphodiesterases.

Chemical Structure

Tracazolate HCl
CAS# 1135210-68-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 576510
Name: Tracazolate HCl
CAS#: 1135210-68-2 (HCl)
Chemical Formula: C16H25ClN4O2
Exact Mass: 0.00
Molecular Weight: 340.850
Elemental Analysis: C, 56.38; H, 7.39; Cl, 10.40; N, 16.44; O, 9.39

Price and Availability

Size Price Availability Quantity
50mg USD 750 2 Weeks
100mg USD 1350 2 Weeks
200mg USD 1950 2 Weeks
500mg USD 2950 2 Weeks
1g USD 4250 2 Weeks
2g USD 7950 2 Weeks
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Related CAS #: 41094-88-6 (free base)   1135210-68-2 (HCl)    

Synonym: ICI 136753; ICI136753; ICI-136753; Tracazolate; Tracazolate HCl;

IUPAC/Chemical Name: 1H-Pyrazolo(3,4-b)pyridine-5-carboxylic acid, 4-(butylamino)-1-ethyl-6-methyl-, ethyl ester, hydrochloride


InChi Code: InChI=1S/C16H24N4O2.ClH/c1-5-8-9-17-14-12-10-18-20(6-2)15(12)19-11(4)13(14)16(21)22-7-3;/h10H,5-9H2,1-4H3,(H,17,19);1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 340.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Thompson SA, Wingrove PB, Connelly L, Whiting PJ, Wafford KA. Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors. Mol Pharmacol. 2002 Apr;61(4):861-9. doi: 10.1124/mol.61.4.861. PMID: 11901225.

2. Melgar MD, Zuleski FR, Malbica JO. Metabolism, disposition, and pharmacokinetics of tracazolate in rat and dog. Drug Metab Dispos. 1984 Jul-Aug;12(4):396-402. PMID: 6148204.

3. Patel JB, Malick JB. Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent. Eur J Pharmacol. 1982 Mar 12;78(3):323-33. doi: 10.1016/0014-2999(82)90034-6. PMID: 6121711.

4. File SE, Pellow S. The anxiolytic but not the sedative properties of tracazolate are reversed by the benzodiazepine receptor antagonist, Ro 15-1788. Neuropsychobiology. 1985;14(4):193-7. doi: 10.1159/000118226. PMID: 2872613.