WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464493
CAS#: 605-32-3
Description: 2-Hydroxyanthraquinone is an anthraquinone that has been found in Spermacoce latifolia and has antibacterial and estrogenic activities. It is active against B. subtilis and B. cereus (MICs = 1.9 and 62.5 µg/ml, respectively). 2-Hydroxyanthraquinone (19 µM) induces estrogen receptor α (ERα) activation in a yeast two-hybrid assay.
MedKoo Cat#: 464493
Name: 2-hATQ
CAS#: 605-32-3
Chemical Formula: C14H8O3
Exact Mass: 224.0473
Molecular Weight: 224.215
Elemental Analysis: C, 75.00; H, 3.60; O, 21.41
Synonym: 2-hATQ; 2 hATQ; 2-Hydroxyanthraquinone; 2 Hydroxyanthraquinone; 2-hydroxy-9,10-Anthraquinone; β-Hydroxyanthraquinone; β Hydroxyanthraquinone; NSC 2595; NSC2595; NSC-2595;
IUPAC/Chemical Name: 2-hydroxyanthracene-9,10-dione
InChi Key: GCDBEYOJCZLKMC-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H8O3/c15-8-5-6-11-12(7-8)14(17)10-4-2-1-3-9(10)13(11)16/h1-7,15H
SMILES Code: O=C1C2=C(C=CC=C2)C(C3=CC(O)=CC=C13)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 5.0 | 22.3 | |
| DMSO | 30.0 | 133.8 |
The following data is based on the product molecular weight 224.215 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Butterworth BE, Mathre OB, Ballinger KE, Adalsteinsson O. Contamination is a frequent confounding factor in toxicology studies with anthraquinone and related compounds. Int J Toxicol. 2004;23(5):335-44. doi: 10.1080/10915810490517072. PMID: 15513832.
2: Mallakin A, McConkey BJ, Miao G, McKibben B, Snieckus V, Dixon DG, Greenberg BM. Impacts of structural photomodification on the toxicity of environmental contaminants: anthracene photooxidation products. Ecotoxicol Environ Saf. 1999 Jun;43(2):204-12. doi: 10.1006/eesa.1999.1764. PMID: 10375423.
3: Ramamoorthy S, Mudgal G, Rajesh D, Nawaz Khan F, Vijayakumar V, Rajasekaran C. Characterisation of novel pH indicator of natural dye Oldenlandia umbellata L. Nat Prod Res. 2009;23(13):1210-7. doi: 10.1080/14786410802696635. PMID: 19731140.
4: Shi Y, Wang CH, Gong XG. Apoptosis-inducing effects of two anthraquinones from Hedyotis diffusa WILLD. Biol Pharm Bull. 2008 Jun;31(6):1075-8. doi: 10.1248/bpb.31.1075. PMID: 18520033.
5: Tikkanen L, Matsushima T, Natori S. Mutagenicity of anthraquinones in the Salmonella preincubation test. Mutat Res. 1983 Mar;116(3-4):297-304. doi: 10.1016/0165-1218(83)90067-8. PMID: 6339896.
6: Hilgert I, Cudlín J, Steinerová N, Vanĕk Z. Antitumour and immunosuppressive activity of hydroxyanthraquinones and their glucosides. Folia Biol (Praha). 1977;23(2):99-109. PMID: 863051.
