ICI-D2138

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576505

CAS#: 140841-32-3

Description: ICI-D2138 is a non-redox inhibitor of 5-lipoxygenase and leukotriene B4 synthesis.


Chemical Structure

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ICI-D2138
CAS# 140841-32-3

Theoretical Analysis

MedKoo Cat#: 576505
Name: ICI-D2138
CAS#: 140841-32-3
Chemical Formula: C23H24FNO4
Exact Mass: 397.1689
Molecular Weight: 397.45
Elemental Analysis: C, 69.51; H, 6.09; F, 4.78; N, 3.52; O, 16.10

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ICID2138; ICI D2138; ICI-D2138; ZD 2138; ZD2138; ZD-2138

IUPAC/Chemical Name: 2(1H)-Quinolinone, 6-((3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy)methyl)-1-methyl-

InChi Key: SLZBEPLWGGRZAY-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H24FNO4/c1-25-21-5-3-16(11-17(21)4-6-22(25)26)15-29-20-13-18(12-19(24)14-20)23(27-2)7-9-28-10-8-23/h3-6,11-14H,7-10,15H2,1-2H3

SMILES Code: COC1(CCOCC1)c2cc(F)cc(OCc3ccc4N(C)C(=O)C=Cc4c3)c2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 397.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. McMillan RM, Spruce KE, Crawley GC, Walker ER, Foster SJ. Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase. Br J Pharmacol. 1992 Dec;107(4):1042-7. doi: 10.1111/j.1476-5381.1992.tb13404.x. PMID: 1334748; PMCID: PMC1907929.

2. Crawley GC, Bird TG, Bruneau P, Dowell RI, Edwards PN, Foster SJ, Girodeau JM, McMillan RM, Walker ER, Waterson D. Structure and activity relationships leading to the discovery of ICI D2138, a selective, potent and orally active inhibitor of 5-lipoxygenase. J Lipid Mediat. 1993 Mar-Apr;6(1-3):249-57. PMID: 8395247.