WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576504
Description: ICI-198157 is a selective beta3-adrenergic agonist of brown adipose tissue and thermogenesis in rat.
MedKoo Cat#: 576504
Chemical Formula: C20H26ClNO6
Exact Mass: 411.1449
Molecular Weight: 411.88
Elemental Analysis: C, 58.32; H, 6.36; Cl, 8.61; N, 3.40; O, 23.31
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Synonym: ICI 198157; ICI198157; ICI-198157
IUPAC/Chemical Name: Acetic acid, (4-(2-((2-hydroxy-3-phenoxypropyl)amino)ethoxy)phenoxy)-, methyl ester hydrochloride, (+-)-
InChi Key: MVQOMOXWRUVMOG-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H25NO6.ClH/c1-24-20(23)15-27-19-9-7-18(8-10-19)25-12-11-21-13-16(22)14-26-17-5-3-2-4-6-17;/h2-10,16,21-22H,11-15H2,1H3;1H
SMILES Code: Cl.COC(=O)COc1ccc(OCCNCC(O)COc2ccccc2)cc1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 411.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Díez-Sampedro A, Pérez M, Cobo MT, Martínez JA, Barber A. Effect of different beta-adrenergic agonists on the intestinal absorption of galactose and phenylalanine. J Pharm Pharmacol. 1998 Aug;50(8):907-11. doi: 10.1111/j.2042-7158.1998.tb04007.x. PMID: 9751456.
2. Howe R, Rao BS, Holloway BR, Stribling D. Selective beta 3-adrenergic agonists of brown adipose tissue and thermogenesis. 1. [4-[2-[(2-Hydroxy-3-phenoxypropyl)amino]ethoxy]phenoxy]acetates. J Med Chem. 1992 May 15;35(10):1751-9. doi: 10.1021/jm00088a009. PMID: 1350309.